Stem cells

Finklea FB, Tian Y, Kerscher P, Seeto WJ, Ellis ME, Lipke EA (2021) Engineered Cardiac Tissue Microsphere Production through Direct Differentiation of Hydrogel-encapsulated Human Pluripotent Stem Cells. Biomaterials:120818.

Häkli M, Kreutzer J, Mäki AJ, Välimäki H, Lappi H, Huhtala H, Kallio P, Aalto-Setälä K, Pekkanen-Mattila M (2021) Human induced pluripotent stem cell-based platform for modeling cardiac ischemia. Sci Rep 11:4153.

Heiney K, Valderhaug V, Ramstad O, Sandvig I, Sandvig A, Nichele S (2021) Hallmarks of Criticality in Neuronal Networks Depend on Cell Type and the Temporal Resolution of Neuronal Avalanches. International Journal of Unconventional Computing 16:303-326.

Hong L, Zhang M, Ly OT, Chen H, Sridhar A, Lambers E, Chalazan B, Youn SW, Maienschein-Cline M, Feferman L, Ong SG, Wu JC, Rehman J, Darbar D (2021) Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation. Stem Cell Reports.

Izsak J, Seth H, Iljin M, Theiss S, Ågren H, Funa K, Aigner L, Hanse E, Illes S (2021) Differential acute impact of therapeutically effective and overdose concentrations of lithium on human neuronal single cell and network function. Transl Psychiatry 11:281.

Mossink B, Verboven AHA, van Hugte EJH, Gunnewiek TMK, Parodi G, Linda K, Schoenmaker C, Kleefstra T, Kozicz T, van Bokhoven H, Schubert D, Kasri NN, Frega M (2021) Human neuronal networks on micro-electrode arrays are a highly robust tool to study disease-specific genotype-phenotype correlations in vitro. bioRxiv:2021.2001.2020.427439.

Niehoff J, Matzkies M, Nguemo F, Hescheler J, Reppel M (2021) The influence of melatonin on the heart rhythm - An in vitro simulation with murine embryonic stem cell derived cardiomyocytes. Biomed Pharmacother 136:111245.

Perkins EM, Burr K, Banerjee P, Mehta AR, Dando O, Selvaraj BT, Suminaite D, Nanda J, Henstridge CM, Gillingwater TH, Hardingham GE, Wyllie DJA, Chandran S, Livesey MR (2021) Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction. Mol Neurodegener 16:13.

Pires Monteiro S, Voogd E, Muzzi L, De Vecchis G, Mossink B, Levers M, Hassink G, van Putten M, le Feber J, Hofmeijer J, Frega M (2021) Neuroprotective effect of hypoxic preconditioning and neuronal activation in a human model of the ischemic penumbra. J Neural Eng.

Ryding M, Gamre M, Nissen MS, Nilsson AC, Okarmus J, Poulsen AAE, Meyer M, Blaabjerg M (2021) Neurodegeneration Induced by Anti-IgLON5 Antibodies Studied in Induced Pluripotent Stem Cell-Derived Human Neurons. Cells 10.

Van Lent J, Verstraelen P, Asselbergh B, Adriaenssens E, Mateiu L, Verbist C, De Winter V, Eggermont K, Van Den Bosch L, De Vos WH, Timmerman V (2021) Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction. Brain.

Almad AA, Taga A, Joseph J, Welsh C, Patankar A, Gross SK, Richard J-P, Pokharel A, Lillo M, Dastgheyb R, Eggan K, Haughey N, Contreras JE, Maragakis NJ (2020) Connexin 43 hemichannels mediate spatial and temporal disease spread in ALS. bioRxiv:2020.2003.2014.990747.

Balafkan N, Mostafavi S, Schubert M, Siller R, Liang KX, Sullivan G, Bindoff LA (2020) A method for differentiating human induced pluripotent stem cells toward functional cardiomyocytes in 96-well microplates. Sci Rep 10:18498.

Cai H, Li B, Bai A, Huang J, Zhan Y, Sun N, Liang Q, Xu C (2020) Establishing a new human hypertrophic cardiomyopathy-specific model using human embryonic stem cells. Exp Cell Res 387:111736.

Chen M, Maimaitili M, Habekost M, Gill KP, Mermet-Joret N, Nabavi S, Febbraro F, Denham M (2020) Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells. Stem Cell Res 48:101945.

Chen S, Hsieh MH, Li SH, Wu J, Weisel RD, Chang Y, Sung HW, Li RK (2020) A conductive cell-delivery construct as a bioengineered patch that can improve electrical propagation and synchronize cardiomyocyte contraction for heart repair. J Control Release 320:73-82.

Di Consiglio E, Pistollato F, Mendoza-De Gyves E, Bal-Price A, Testai E (2020) Integrating biokinetics and in vitro studies to evaluate developmental neurotoxicity induced by chlorpyrifos in human iPSC-derived neural stem cells undergoing differentiation towards neuronal and glial cells. Reprod Toxicol.

Fischer S, Schlotthauer I, Kizner V, Macartney T, Dorner-Ciossek C, Gillardon F (2020) Loss-of-function Mutations of CUL3, a High Confidence Gene for Psychiatric Disorders, Lead to Aberrant Neurodevelopment In Human Induced Pluripotent Stem Cells. Neuroscience.

Izsak J, Seth H, Theiss S, Hanse E, Illes S (2020) Human Cerebrospinal Fluid Promotes Neuronal Circuit Maturation of Human Induced Pluripotent Stem Cell-Derived 3D Neural Aggregates. Stem Cell Reports 14:1044-1059.

Manzati M, Sorbo T, Giugliano M, Ballerini L (2020) Foetal neural progenitors contribute to postnatal circuits formation ex vivo: an electrophysiological investigation. Mol Brain 13:78.

Mayer M, Arrizabalaga O, Ciba M, Schroeder IS, Ritter S, Thielemann C (2020) Novel in vitro assay to investigate radiation induced changes in the functionality of human embryonic stem cell-derived neurospheres. Neurotoxicology 79:40-47.

Mossink B, van Rhijn J-R, Wang S, van Hugte EJH, Linda K, Bak J, Verboven AHA, Selten M, Anania A, Jansen S, Keller JM, Gunnewiek TK, Schoenmaker C, Oudakker A, Frega M, van Bokhoven H, Schubert D, Kasri NN (2020) Cadherin-13 is a critical regulator of GABAergic modulation in human stem cell derived neuronal networks. bioRxiv:2020.2005.2007.082453.

Pagan-Diaz GJ, Drnevich J, Ramos-Cruz KP, Sam R, Sengupta P, Bashir R (2020) Modulating electrophysiology of motor neural networks via optogenetic stimulation during neurogenesis and synaptogenesis. Sci Rep 10:12460.

Pelkonen A, Mzezewa R, Sukki L, Ryynänen T, Kreutzer J, Hyvärinen T, Vinogradov A, Aarnos L, Lekkala J, Kallio P, Narkilahti S (2020) A modular brain-on-a-chip for modelling epileptic seizures with functionally connected human neuronal networks. Biosensors and Bioelectronics 168:112553.

Rajbhandari S, Beppu M, Takagi T, Nakano-Doi A, Nakagomi N, Matsuyama T, Nakagomi T, Yoshimura S (2020) Ischemia-Induced Multipotent Stem Cells Isolated from Stroke Patients Exhibit Higher Neurogenic Differentiation Potential than Bone Marrow-Derived Mesenchymal Stem Cells. Stem Cells Dev.

Satir TM, Nazir FH, Vizlin-Hodzic D, Hardselius E, Blennow K, Wray S, Zetterberg H, Agholme L, Bergstrom P (2020) Accelerated neuronal and synaptic maturation by BrainPhys medium increases Abeta secretion and alters Abeta peptide ratios from iPSC-derived cortical neurons. Sci Rep 10:601.

Schneider J, Pease DR, Navaratnarajah CK, Halfmann P, Clemens DJ, Ye D, Kim CS, Barkhymer A, Cohle S, Banks A, Mehta A, Rantus J, Emmerzaal TL, Kozicz T, Howell KG, Charlesworth JE, Christensen TA, Yoshihiro Kawaoka Y, Cooper LT, Ackerman MJ, Cattaneo R (2020) SARS-CoV-2 direct cardiac damage through spike-mediated cardiomyocyte fusion Nature Research.

Solomon E, Davis-Anderson K, Hovde B, Micheva-Viteva SN, Harris JF, Twary SN, Iyer R (2020) Global Transcriptome Profile of the Developmental Principles of in Vitro iPSC-to-Motor Neuron Differentiation. BMC Molecular and Cell Biology.

Sowmithra S, Jain NK, Bhonde R, Datta I (2020) Recovery of Human Embryonic Stem Cells-Derived Neural Progenitors Exposed to Hypoxic-Ischemic-Reperfusion Injury by Indirect Exposure to Wharton's Jelly Mesenchymal Stem Cells Through Phosphatidyl-inositol-3-Kinase Pathway. Cell Mol Neurobiol.

Stauske M, Rodriguez Polo I, Haas W, Knorr DY, Borchert T, Streckfuss-Bömeke K, Dressel R, Bartels I, Tiburcy M, Zimmermann WH, Behr R (2020) Non-Human Primate iPSC Generation, Cultivation, and Cardiac Differentiation under Chemically Defined Conditions. Cells 9.

Valderhaug VD, Heiney K, Ramstad OH, Bråthen G, Kuan W-L, Nichele S, Sandvig A, Sandvig I (2020) Criticality as a measure of developing proteinopathy in engineered human neural networks. bioRxiv:2020.2005.2003.074666.

van Veldhoven JPD, Campostrini G, van Gessel CJE, Ward-van Oostwaard D, Liu R, Mummery CL, Bellin M, Ijzerman AP (2020) Targeting the Kv11.1 (hERG) channel with allosteric modulators. Synthesis and biological evaluation of three novel series of LUF7346 derivatives. European Journal of Medicinal Chemistry:113033.

Wang L, Ma H, Huang P, Xie Y, Near D, Wang H, Xu J, Yang Y, Xu Y, Garbutt T, Zhou Y, Liu Z, Yin C, Bressan M, Taylor JM, Liu J, Qian L (2020) Down-regulation of Beclin1 promotes direct cardiac reprogramming. Sci Transl Med 12.

Amend N, Thiermann H, Worek F, Wille T (2019) The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM). Toxicol Lett 308:1-6.

Bauer US, van de Wijdeven R, Raveendran RN, Fiskum V, Kentros C, Sandvig I, Sandvig A (2019) Modelling functional human neuromuscular junctions in a differentially-perturbable microfluidic environment, validated through recombinant monosynaptic pseudotyped ΔG-rabies virus tracing. bioRxiv:745513.

Beppu M, Nakagomi T, Takagi T, Nakano-Doi A, Sakuma R, Kuramoto Y, Tatebayashi K, Matsuyama T, Yoshimura S (2019) Isolation and characterization of cerebellum-derived stem cells in post-stroke human brain. Stem Cells Dev.

Donadoni M, Cicalese S, Sarkar DK, Chang SL, Sariyer IK (2019) Alcohol exposure alters pre-mRNA splicing of antiapoptotic Mcl-1L isoform and induces apoptosis in neural progenitors and immature neurons. Cell Death Dis 10:447.

Frega M, Linda K, Keller JM, Gumus-Akay G, Mossink B, van Rhijn JR, Negwer M, Klein Gunnewiek T, Foreman K, Kompier N, Schoenmaker C, van den Akker W, van der Werf I, Oudakker A, Zhou H, Kleefstra T, Schubert D, van Bokhoven H, Nadif Kasri N (2019) Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling. Nat Commun 10:4928.

Gilmore JL, Xiao HY, Dhar TGM, Yang MG, Xiao Z, Xie J, Lehman-McKeeman LD, Gong L, Sun H, Lecureux L, Chen C, Wu DR, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Borowski V, Warrack BM, Li Y, Shi H, Levesque PC, Yang Z, Marino AM, Cornelius G, D'Arienzo CJ, Mathur A, Rampulla R, Gupta A, Pragalathan B, Shen DR, Cvijic ME, Salter-Cid LM, Carter PH, Dyckman AJ (2019) Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials. J Med Chem 62:2265-2285.

Kizner V, Fischer S, Naujock M (2019) Multielectrode Array (MEA)-Based Detection of Spontaneous Network Activity in Human iPSC-Derived Cortical Neurons. Methods Mol Biol 1994:209-216.

Kizner V, Naujock M, Fischer S, Jager S, Reich S, Schlotthauer I, Zuckschwerdt K, Geiger T, Hildebrandt T, Lawless N, Macartney T, Dorner-Ciossek C, Gillardon F (2019) CRISPR/Cas9-mediated Knockout of the Neuropsychiatric Risk Gene KCTD13 Causes Developmental Deficits in Human Cortical Neurons Derived from Induced Pluripotent Stem Cells. Mol Neurobiol.

Klein Gunnewiek TM, Van Hugte EJH, Frega M, Guardia GS, Foreman KB, Panneman D, Mossink B, Linda K, Keller JM, Schubert D, Cassiman D, Morava E, Rodenburg R, Perales-Clemente E, Nelson TJ, Kasri NN, Kozicz T (2019) Mitochondrial dysfunction impairs human neuronal development and reduces neuronal network activity and synchronicity. bioRxiv:720227.

Kraushaar U, Guenther E (2019) Assay Procedures for Compound Testing of hiPSC-Derived Cardiomyocytes Using Multiwell Microelectrode Arrays. Methods Mol Biol 1994:197-208.

Kugler P, Rast G, Guth BD (2019) Comparison of in vitro and computational experiments on the relation of inter-beat interval and duration of repolarization in a specific type of human induced pluripotent stem cell-derived cardiomyocytes. PLoS ONE 14:e0221763.

Kussauer S, David R, Lemcke H (2019) hiPSCs Derived Cardiac Cells for Drug and Toxicity Screening and Disease Modeling: What Micro- Electrode-Array Analyses Can Tell Us. Cells 8.

Lees JG, Kong AM, Chen YC, Sivakumaran P, Hernandez D, Pebay A, Harvey AI, Gardener DK, Lim SY (2019) Mitochondrial Fusion by M1 Promotes Embryoid Body Cardiac Differentiation of Human Pluripotent Stem Cells. Stem Cells International 2019:12.

Li J, Zhang L, Yu L, Minami I, Hörning M, Dong J, Qiao J, Fujimoto N, Shiba Y, Zhao Y, Tang F, Miyagawa S, Chen Y, Sawa Y, Tang C, Liu L (2019) Rapid pacing by circulating traveling waves improves maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring. bioRxiv:717108.

McAleer CW, Pointon A, Long CJ, Brighton RL, Wilkin BD, Bridges LR, Narasimhan Sriram N, Fabre K, McDougall R, Muse VP, Mettetal JT, Srivastava A, Williams D, Schnepper MT, Roles JL, Shuler ML, Hickman JJ, Ewart L (2019) On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships. Sci Rep 9:9619.

Niehoff J, Matzkies M, Nguemo F, Hescheler J, Reppel M (2019) The Effect of Antiarrhythmic Drugs on the Beat Rate Variability of Human Embryonic and Human Induced Pluripotent Stem Cell Derived Cardiomyocytes. Sci Rep 9:14106.

Oleaga C, Jalilvand G, Legters G, Martin C, Ekman G, McAleer CW, Long CJ, Hickman JJ (2019) A human in vitro platform for the evaluation of pharmacology strategies in cardiac ischemia. APL Bioeng 3:036103.

Papariello A, Newell-Litwa K (2019) Human-Derived Brain Models: Windows Into Neuropsychiatric Disorders and Drug Therapies. Assay Drug Dev Technol.

Park SJ, Kim RY, Park BW, Lee S, Choi SW, Park JH, Choi JJ, Kim SW, Jang J, Cho DW, Chung HM, Moon SH, Ban K, Park HJ (2019) Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction. Nat Commun 10:3123.

Patel AM, Wierda K, Thorrez L, van Putten M, De Smedt J, Ribeiro L, Tricot T, Gajjar M, Duelen R, Van Damme P, De Waele L, Goemans N, Tanganyika-de Winter C, Costamagna D, Aartsma-Rus A, van Duyvenvoorde H, Sampaolesi M, Buyse GM, Verfaillie CM (2019) Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes. Transl Psychiatry 9:200.

Pianezzi E, Altomare C, Bolis S, Balbi C, Torre T, Rinaldi A, Camici GG, Barile L, Vassalli G (2019) Role of somatic cell sources in the maturation degree of human induced pluripotent stem cell-derived cardiomyocytes. Biochim Biophys Acta Mol Cell Res:118538.

Seo HW, Kim N, Ahn J, Cha S, Goo YS, Kim S (2019) A 3D flexible microelectrode array for subretinal stimulation. J Neural Eng 16:056016.

Sfakianou A (2019) Functional Characterization of Human iPSC-Derived Neural Networks using MEA Systems for in vitro Modeling of Psychiatric Disorders.

Shah D, Virtanen L, Prajapati C, Kiamehr M, Gullmets J, West G, Kreutzer J, Pekkanen-Mattila M, Helio T, Kallio P, Taimen P, Aalto-Setala K (2019) Modeling of LMNA-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cells. Cells 8.

Shi Y, van Rhijn JR, Bormann M, Mossink B, Frega M, Hakobjan M, Kittel-Schneider S, Schubert D, Brunner H, Franke B, Kasri NN (2019) Brunner Syndrome associated MAOA dysfunction in human induced dopaminergic neurons results in dysregulated NMDAR expression and increased network activity. bioRxiv:741108.

Sohn PD, Huang CT, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok SA, Freilich R, Baik J, He M, Gong S, Roberson ED, Karch CM, Gestwicki JE, Xu K, Kosik KS, Gan L (2019) Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis. Neuron.

Taga A, Dastgheyb R, Habela C, Joseph J, Richard J-P, Gross SK, Lauria G, Lee G, Haughey N, Maragakis NJ (2019) Role of human induced pluripotent stem cell-derived spinal cord astrocytes in the functional maturation of motor neurons in a multielectrode array system. bioRxiv:614297.

Valderhaug VD, Glomm WR, Sandru EM, Yasuda M, Sandvig A, Sandvig I (2019) Formation of neural networks with structural and functional features consistent with small-world network topology on surface-grafted polymer particles. Royal Society Open Science 6:191086.

van Meer BJ, Krotenberg A, Sala L, Davis RP, Eschenhagen T, Denning C, Tertoolen LGJ, Mummery CL (2019) Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes. Nat Commun 10:4325.

Vanninen SUM, Kujala V, Porsti I, Aalto-Setala K (2019) A Quantitative Comparison of 12-Lead Electrocardiograms and In Vitro Field Potentials of Stem Cell-Derived Cardiomyocytes. International Journal of Stem Cell Research and Therapeutics.

Varzideh F, Mahmoudi E, Pahlavan S (2019) Coculture with noncardiac cells promoted maturation of human stem cell-derived cardiomyocyte microtissues. J Cell Biochem.

Yang H, Zhong W, Hamidi MR, Zhou G, Liu C (2019) Functional improvement and maturation of human cardiomyocytes derived from human pluripotent stem cells by barbaloin preconditioning. Acta Biochim Biophys Sin (Shanghai).

Zhao Y, Guzman E, Audouard M, Cheng Z, Hansma P, Kosik KS, Petzold L (2019) A Deep Learning Framework for Classification of in vitro Multi-Electrode Array Recordings. arXiv 1906.02241.

Zlochiver V, Kroboth SL, Beal CR, Cook JA, Joshi-Mukherjee R (2019) Human iPSC-Derived Cardiomyocyte Networks on Multiwell Micro-electrode Arrays for Recurrent Action Potential Recordings. JoVE:e59906.

Alshawaf AJ, Viventi S, Qiu W, D'Abaco G, Nayagam B, Erlichster M, Chana G, Everall I, Ivanusic J, Skafidas E, Dottori M (2018) Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells. Sci Rep 8:603.

Becker BV, Seeger T, Beiert T, Antwerpen M, Palnek A, Port M, Ullmann R (2018) Impact of Ionizing Radiation on Electrophysiological Behavior of Human-induced Ipsc-derived Cardiomyocytes on Multielectrode Arrays. Health Phys 115:21-28.

Brouwer S, Hoffmeister T, Gresch A, Schonhoff L, Dufer M (2018) Resveratrol Influences Pancreatic Islets by Opposing Effects on Electrical Activity and Insulin Release. Mol Nutr Food Res.

Cvetkovic C, Basu N, Krencik R (2018) Synaptic Microcircuit Modeling with 3D Cocultures of Astrocytes and Neurons from Human Pluripotent Stem Cells. J Vis Exp.

Dahlmann J, Awad G, Dolny C, Weinert S, Richter K, Fischer KD, Munsch T, Lessmann V, Volleth M, Zenker M, Chen Y, Merkl C, Schnieke A, Baraki H, Kutschka I, Kensah G (2018) Generation of functional cardiomyocytes from rat embryonic and induced pluripotent stem cells using feeder-free expansion and differentiation in suspension culture. PLoS ONE 13:e0192652.

Edwards SL, Zlochiver V, Conrad DB, Vaidyanathan R, Valiquette AM, Joshi-Mukherjee R (2018) A Multiwell Cardiac muGMEA Platform for Action Potential Recordings from Human iPSC-Derived Cardiomyocyte Constructs. Stem Cell Reports.

Frega M, Mossink B, Linda K, Keller J, Schubert D, Kasri NN (2018) Brain-on-a chip technologies for investigating neuronal diseases: Toward precision medicine applications. 2018 IEEE International Symposium on Circuits and Systems (ISCAS):1-3.

Gamble JR, Zhang ET, Iyer N, Sakiyama-Elbert S, Barbour DL (2018) In Vitro Assay for the Detection of Network Connectivity in Embryonic Stem Cell-Derived Cultures. bioRxiv.

Ghazizadeh Z, Fattahi F, Mirzaei M, Bayersaikhan D, Lee J, Chae S, Hwang D, Byun K, Tabar MS, Taleahmad S, Mirshahvaladi S, Shabani P, Fonoudi H, Haynes PA, Baharvand H, Aghdami N, Evans T, Lee B, Salekdeh GH (2018) Prospective Isolation of ISL1(+) Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy. Stem Cell Reports 10:848-859.

Golgooni Z, Mirsadeghi S, Soleymani Baghshah M, Ataee P, Baharvand H, Pahlavan S, Rabiee HR (2018) Deep Learning Based Proarrhythmia Analysis Using Field Potentials Recorded from Human Pluripotent Stem Cells Derived Cardiomyocytes. bioRxiv:244442.

Hoque A, Sivakumaran P, Bond ST, Ling NXY, Kong AM, Scott JW, Bandara N, Hernandez D, Liu GS, Wong RCB, Ryan MT, Hausenloy DJ, Kemp BE, Oakhill JS, Drew BG, Pebay A, Lim SY (2018) Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells. Cell Death Discov 4:39.

Kaiser A (2018) Auditory Organotypic Cultures and Progenitor Cell Implantation.

Krantis A, Tam T, Chichirau A, Kajura K (2018) Cryopreserved Neonatal Rat Ventricular Cardiomyocytes in Long-term Culture Display Normal Morphology and Functional Activity. In.

Makinen M (2018) Functionality of Brain in a Dish. Faculty of Medicine and Life Sciences.

Makinen ME, Yla-Outinen L, Narkilahti S (2018) GABA and Gap Junctions in the Development of Synchronized Activity in Human Pluripotent Stem Cell-Derived Neural Networks. Front Cell Neurosci 12:56.

Millard D, Dang Q, Shi H, Zhang X, Strock C, Kraushaar U, Zeng H, Levesque P, Lu HR, Guillon JM, Wu JC, Li Y, Luerman G, Anson B, Guo L, Clements M, Abassi YA, Ross J, Pierson J, Gintant G (2018) Cross-Site Reliability of Human Induced Pluripotent Stem-Cell Derived Cardiomyocyte Based Safety Assays using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study. Toxicol Sci.

Mulder P, de Korte T, Dragicevic E, Kraushaar U, Printemps R, Vlaming MLH, Braam SR, Valentin JP (2018) Predicting cardiac safety using human induced pluripotent stem cell-derived cardiomyocytes combined with multi-electrode array (MEA) technology: A conference report. J Pharmacol Toxicol Methods 91:36-42.

Paavilainen T, Pelkonen A, Makinen ME, Peltola M, Huhtala H, Fayuk D, Narkilahti S (2018) Effect of prolonged differentiation on functional maturation of human pluripotent stem cell-derived neuronal cultures. Stem Cell Res 27:151-161.

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Petersen ED, Zenchak JR, Lossia OV, Hochgeschwender U (2018) Neural Stem Cells Derived Directly from Adipose Tissue. Stem Cells Dev 27:637-647.

Pfeiffer MJ, Quaranta R, Piccini I, Fell J, Rao J, Ropke A, Seebohm G, Greber B (2018) Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES. Nat Commun 9:440.

Plumbly W, Brandon NJ, Deeb TZ, Hall J, Harwood AJ (2018) L-type voltage-gated calcium channel regulation of in vitro human cortical neuronal networks BioRxiv.

Sakuma R, Takahashi A, Nakano-Doi A, Sawada R, Kamachi S, Beppu M, Takagi T, Yoshimura S, Matsuyama T, Nakagomi T (2018) Comparative characterization of ischemia-induced brain multipotent stem cells with mesenchymal stem cells: Similarities and differences. Stem Cells Dev.

Shall G, Menosky M, Decker S, Nethala P, Welchko R, Leveque X, Lu M, Sandstrom M, Hochgeschwender U, Rossignol J, Dunbar G (2018) Effects of Passage Number and Differentiation Protocol on the Generation of Dopaminergic Neurons from Rat Bone Marrow-Derived Mesenchymal Stem Cells. Int J Mol Sci 19.

Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, Woolwine P, Huang M, Cowan MJ, Ge B, Koutsodendris N, Sandor KP, Komberg J, Vangoor VR, Senthilkumar K, Hennes V, Seah C, Nelson AR, Cheng TY, Lee SJ, August PR, Chen JA, Wisniewski N, Hanson-Smith V, Belgard TG, Zhang A, Coba M, Grunseich C, Ward ME, van den Berg LH, Pasterkamp RJ, Trotti D, Zlokovic BV, Ichida JK (2018) Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nat Med 24:313-325.

Sottas V, Wahl CM, Trache MC, Bartolf-Kopp M, Cambridge S, Hecker M, Ullrich ND (2018) Improving electrical properties of iPSC-cardiomyocytes by enhancing Cx43 expression. J Mol Cell Cardiol 120:31-41.

Sumitha R, Manjunatha VM, Sabitha RK, Alladi PA, Nalini A, Rao LT, Chandrasekhar Sagar BK, Steinbusch HWM, Kramer BW, Sathyaprabha TN, Raju TR (2018) Cerebrospinal Fluid from Patients with Sporadic Amyotrophic Lateral Sclerosis Induces Degeneration of Motor Neurons Derived from Human Embryonic Stem Cells. Mol Neurobiol.

Telezhkin V, Straccia M, Yarova P, Pardo M, Yung S, Vinh NN, Hancock JM, Barriga GG, Brown DA, Rosser AE, Brown JT, Canals JM, Randall AD, Allen ND, Kemp PJ (2018) Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons. Pflugers Arch.

Tourigny DS, Abdul Karim MK, Echeveste R, Kotter MRN, O'Neill JS (2018) Energetic substrate availability regulates synchronous activity in an excitatory neural network. bioRxiv:363671.

Yamauchi K, Li J, Morikawa K, Liu L, Shirayoshi Y, Nakatsuji N, Elliott DA, Hisatome I, Suemori H (2018) Isolation and characterization of ventricular-like cells derived from NKX2-5(eGFP/w) and MLC2v(mCherry/w) double knock-in human pluripotent stem cells. Biochem Biophys Res Commun 495:1278-1284.

Yap L, Wang JW, Moreno-Moral A, Chong LY, Sun Y, Harmston N, Wang X, Chong SY, Ohman MK, Wei H, Bunte R, Ghosh S, Cook S, Hovatta O, de Kleijn DPV, Petretto E, Tryggvason K (2018) In vivo generation of post-infarct mouse cardiac muscle by cardiomyocyte progenitors produced with a reproducible laminin-promoted human stem cell differentiation system. bioRxiv:478883.

Aaser P, Knudsen M, Ramstad OH, van de Wijdeven R, Nichele S, Sandvig I, Tufte G, Bauer US, Halaas O, Hendseth S, Sandvig A, Valderhaug V (2017) Towards making a cyborg: A closed-loop reservoir-neuro system. In: ECAL 2017, pp 430-437. Lyon: MIT Press.

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