ME2100-Systems

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Overview

The ME2100-System is a tethered in vivo recording system. It is the complete setup for anesthetized/head-fixed animals, including everything you need for your experiment.

The system consists of a signal collector unit (MCS-SCU) for up to four headstages, which also contains a connector for up to four outputs for optical stimulation (optogenetics). The signal collector is connected via eSATA cable to the interface board. Up to two signal collectors can be connected to one IFB-C multiboot interface board. Headstages have 32 recording channels plus ground and reference inputs. Amplifier, stimulators and A/D converters are all directly on the headstage, which allows low-noise, high quality data acquisition.

The stimulator units can be connected by software command to any of the recording channels, or to a connector for an external stimulation electrode, which is also located at the headstage. Each of the 32 channels can be used for recording or stimulation, whereas 2 channels can be used for external stimulation electrodes as well.

With a multifold ME2100-System up to two signal collectors can be connected to one interface board, thereby creating a system with 8 headstages for parallel recordings.

Key Features

Up to eight 32 channel headstages
Sampling with up to 50 kHz per channel
24 bit resolution
Filter bandwidth adjustable via software
Integrated stimulation possible on each electrode with blanking feature
Programmable output for optical stimulation

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IFB-C

As part of the system, the IFB-C multiboot is a new interface board generation which is able to receive data from a MEA2100(-Mini)-Headstage, a Multiwell-MEA-Headstage, a CMOS-MEA5000-Headstage, a MEA2100-Beta-Screen-Headstage, a ME2100-Headstage, or a W2100-Receiver. This makes cost-effective combinations with only one interface board and multiple recording systems possible. You can establish for example your experiments on 60, 120, or 256 electrodes with the MEA2100-System, then add the Multiwell-MEA-Headstage and start high-throughput screening. It's also possible to use the same interface board for in vitro MEA experiments and tethered / wireless in vivo recordings. This leaves you with even more flexibility in switching between possible configurations for your specific research needs.

Key features:

Real-time signal detection and feedback*
Freely programmable DSP*
Multiple inputs/outputs, including digital, analog, and audio
SuperSpeed USB 3.0 ports

* applicable for MEA2100(-Mini), ME2100, and W2100

Read more technical specifications

Description

System components

The ME2100-System consists of an interface board (IFB), a signal collector unit (SCU) and the headstage amplifiers.

The interface board transfers the data to the computer via USB 3.0 and can be used for a variety of applications. The same interface board, that you now get for your ME2100-System, can also be used e.g. for a Wireless-System. All you have to do is add receiver and wireless headstages, and you have complete Wireless-System. You can also use the same interface board for in vitro applications, by adding a MEA2100, Multiwell or CMOS headstage.

The signal collector unit gathers all data from the headstages and transfers them to the interface board. You can connect up to 4 headstages to each SCU, while 2 SCUs can be connected to one IFB. The signal collector unit can also control up to four optical stimulation units including high power LED.

The headstage amplifier is the connection to the probe. It amplifies 32 channels right at the signal source and digitizes the data at a 24bit resolution with 50 kHz sampling rate per channel, minimizing noise and thus optimizing the signal-to-noise ratio. Apart from amplifier and A/D converter, the headstages also include a 2-channel stimulus generator. The headstage is attached to a rod mount, so you can easily fix it to a micromanipulator.

Powerful headstages

The ME2100-HS32 headstages combine many functions, while still being relatively small in size (50 mm x 72.5 mm x 8 mm). With the headstages, you can:

Select any of the 32 electrodes as recording or stimulation electrode
Control two external stimulation electrodes (while still recording from the other 32 electrodes)
Freely select the reference electrode (any of the 32 electrodes can be selected via software)

Apart from the stimulation options, the headstages guarantee very exact data, because they sample the incoming signals at 50 kHz per channel at a resolution of 24bit (unmatched in the industry). They can do all this while keeping an ultra-low noise level (1µVRMS) and offering a large signal input range (±1.25V).

The ME2100-µPA-32 is a small sized micro preamplifier for ME2100-System for recording only.

Features are:

Recording from 32 electrode inputs
Common ground, and additional reference electrode input.
Small size 24 mm x 25 mm x 3 mm (W x D x H)
36-pin double-row Omnetics A79023-001 input connector

Signal collector unit

The signal collector unit receives data from up to four headstages. Two signal collector units can be connected to one interface board.

Apart from receiving and transferring data, the SCU is also able to control up to four optical stimulation units, including high power LED.

Interface board

IFB-C The interface board receives data from the signal collector unit via iX industrial type B cable. In the interface board, you find a freely programmable digital signal processor, which can be used for real-time signal detection and feedback. Moreover, you find various analog and digital in- and outputs for synchronization with other instruments. The interface board connects to the computer via USB 3.0 SuperSpeed.

The IFB-Cis a new interface board generation which is able to receive data from MEA2100-Headstages, Multiwell-MEA-Headstage, CMOS-MEA5000-Headstage, ME2100-Systems or W2100-Systems. This makes cost-effective combinations with only one interface board and multiple recording systems possible. You can establish for example your experiments on 60, 120, or 256 electrodes with the MEA2100-System, then add the Multiwell-MEA-Headstage and start high-throughput screening. It's also possible to use the same interface board for in vitro MEA experiments and tethered / wireless in vivo recordings. This leaves you with even more flexibility in switching between possible configurations for your specific research needs.

Higher channel count with 8 headstages

The ME2100-System offers the possibility to record from up to 8 headstages.

You can connect two signal collector units to one interface board. Each signal collector unit can receive data from up to four headstages. Thereby, you can build a system with 8 headstages, recording from 256 channels.

The interface board and signal collectors are equipped for this high channel count from the beginning. This way, you can start with one headstage (32 channels) and add-on more as you go. This gives you the flexibility to adjust the system to your changing experimental needs.

Electrode arrays

The ME2100-System can be operated with most commercially available probes.

Multi Channel Systems offers flexible MEAs, made of polyimide foil. The FlexMEA32 and EcoFlexMEA36 can be connected directly to the ME2100-headstage.

You can also use other electrode arrays, for example probes from Neuronexus Technologies or ATLAS Neuroengineering.

Probes with Omnetics connector can be connected via an adapter. We have a wide range of adapters available. If you do not find the one you need, please contact us. We will certainly find a solution that fits your needs.

Real-time signal detection and feedback

The real-time signal detection/feedback is an advantageous feature if you need fast and predictable reactions related to recorded analog signals with minimum time delay. Before, the signal had to be analyzed by the computer, which led to an unpredictable time delay of the stimulus of at least 100 ms. By moving the analysis from the PC to the DSP (Digital Signal Processor) integrated in the ME2100-System, the detour is obsolete and the time delay is now far below 1 ms. All you need to do is to define the condition for the feedback and download it to the ME2100-System (1). During recording (2), the DSP filters the data and detects spikes (3), checking whether your condition is fulfilled. When a designated event is detected, the integrated stimulus generator generates the stimulus pulse (4).

Computer and software

The last component of the system is the computer with the software package Multi Channel Suite. The computer is not included in the scope of delivery; however, you can use any computer with a USB connector. What is included, is the Multi Channel Suite software.

It consists of three programs and updates are available for free here.

Multi Channel Experimenter is the data acquisition and online analysis tool. With an easy-to-use drag’n’drop interface, you simply create your virtual experiment with e.g. data source, filters, spike detection, and recorder. The software indicates the battery level and signal quality and displays the data in real-time.
Multi Channel Analyzer is the offline analysis tool. You just import the data recorded with the Multi Channel Experimenter and then define your in-depth analysis with more instruments. The Multi Channel Analyzer also supports synchronized video input. This is an advantageous feature when doing behavioral research with freely moving animals. The video data and electrophysiological recordings are displayed in parallel and you can easily skip through the data from one event to the next.
Multi Channel DataManager facilitates the data export for analysis with third-party programs. It supports all files generated with the Multi Channel Experimenter and then exports the data into HDF5 (e.g. Matlab, Python), .nex (Neuroexplorer) or .ced (Spike 2). Independent of the file format, the export is done quickly and a data compresssion is included.

Acute and chronic in vivo recordings

The ME2100-System is compatible with all kinds of in vivo electrode arrays on the market. Spike and LFP activity from acute or chronically implanted electrodes can be recorded with high resolution. It is possible to monitor any channel as an audio output in real-time, which helps positioning the electrode in the brain. Raw data and detected spikes can be monitored continuously. Additionally, the software offers on-line filtering, simple or complex references, and timer controlled automated recordings.

Support and Sales team: Always there for you

Multi Channel Systems has a team of highly-qualified scientists, whose only task is to help you with any issue you might have. No matter whether you want to know whether your biological sample is suitable for MEA recordings or if you have a specific software question: Our support team is here to help you.

We have scientists who earned their PhDs in the fields of biology, biophysics, and biochemistry and specialized in:

Neuronal electrophysiology
Cardiac electrophysiology
Xenopus oocyte research
Patch Clamp

Our sales team has years of experience in electrophysiology, too. They can help you in choosing the right system for your specific application, give you advice on the general set-up and useful accessories. They are happy to visit you in your lab anytime to:

Make a demonstration of our systems
Help you with the installation of a new system
Give you training on hard- and software
Discuss any issues you might have with your application

Worldwide, we are supported by our distribution partners. We have long-lasting cooperations with all of our partners and they are regularly trained on our equipment. Be sure that they have the expertise to advise you on all MCS-Systems.

Please do not hesitate to contact us. Normally, we reply to you within 24 hours. You can contact us via:

Phone +49 7121 90925 25
Email support [at] multichannelsystems.com (Support Team); sales [at] multichannelsystems.com (Sales Team)
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Products

Documents

Manual:

MCS_ME2100-System_Manual.pdf

Data sheet:

MCS_ME2100-System_Datasheet.pdf

Brochure:

ME2100_Brochure.pdf

Accessories

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Publications

Please note: Currently, our publications library includes articles up to 2021 only. Contact us for publications from 2022 – present. Contact Us

Oesterle J, Behrens C, Schröder C, Herrmann T, Euler T, Franke K, Smith RG, Zeck G, Berens P (2020) Bayesian inference for biophysical neuron models enables stimulus optimization for retinal neuroprosthetics. bioRxiv:2020.2001.2008.898759.

www.multichannelsystems.com

Innovations in Electrophysiology

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Key Features

IFB-C

Key features:

ME2100-System

ME2100-HS32-M-3m

ME2100-µPA-32

ME2100-µPA-16

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IFB-C

ME2100-HS32-M-3m

ME2100-µPA-32

ME2100-µPA-16

MCS-SCU-in-vivo

NN-RM

HPU160-S

HPU160-L

HPU290-S

HPU290-L

ADPT-ME2100-HS32-OM

ADPT-EcoFlexMEA36-STIM

ADPT-FM-32

ADPT-FM-72

ADPT-NN-16/32

ADPT-NN-32

ADPT-NN-OM32-STIM

ADPT-NN-64-ME2100

Warming plate (TCW220x120)

C-BNC-Lemo1m

C-4xBNC-Lemo0.5m

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ME2100-Systems

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Key Features

IFB-C

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