The trusted Patch Clamp technique is used in electrophysiological studies of ion channels in tissue sections, individual living cells or patches of cell membrane.
Voltage clamp or current clamp technique is performed in any type of excitable cells, mostly neurons, cardiomyocytes, pancreatic beta cells or muscle fibers. Experiments include slice-recordings, single-cell-layer-recordings, in vivo-recordings, whole-cell-recordings, and single-channel-recordings.