Pharmacology (cardio)

Liu JYH, Du P, Lu Z, Kung JSC, Huang IB, Hui JCM, Ng HSH, Ngan MP, Cui D, Jiang B, Chan SW, Rudd JA (2021) Involvement of TRPV1 and TRPA1 in the modulation of pacemaker potentials in the mouse ileum. Cell Calcium 97:102417.

Ma S, Ma J, Tu Q, Zheng C, Chen Q, Lv W (2020) Isoproterenol Increases Left Atrial Fibrosis and Susceptibility to Atrial Fibrillation by Inducing Atrial Ischemic Infarction in Rats. Front Pharmacol 11:493.

Mustroph J, Drzymalski M, Baier M, Pabel S, Biedermann A, Memmel B, Durczok M, Neef S, Sag CM, Floerchinger B, Rupprecht L, Schmid C, Zausig Y, Bégis G, Briand V, Ozoux M-L, Tamarelle D, Ballet V, Janiak P, Beauverger P, Maier LS, Wagner S (2020) The oral Ca/calmodulin-dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure. ESC Heart Failure n/a.

Shah D (2020) Heart Disease on a Dish. Faculty of Medicine and Health Technology

van Veldhoven JPD, Campostrini G, van Gessel CJE, Ward-van Oostwaard D, Liu R, Mummery CL, Bellin M, Ijzerman AP (2020) Targeting the Kv11.1 (hERG) channel with allosteric modulators. Synthesis and biological evaluation of three novel series of LUF7346 derivatives. European Journal of Medicinal Chemistry:113033.

Amend N, Thiermann H, Worek F, Wille T (2019) The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM). Toxicol Lett 308:1-6.

Gilmore JL, Xiao HY, Dhar TGM, Yang MG, Xiao Z, Xie J, Lehman-McKeeman LD, Gong L, Sun H, Lecureux L, Chen C, Wu DR, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Borowski V, Warrack BM, Li Y, Shi H, Levesque PC, Yang Z, Marino AM, Cornelius G, D'Arienzo CJ, Mathur A, Rampulla R, Gupta A, Pragalathan B, Shen DR, Cvijic ME, Salter-Cid LM, Carter PH, Dyckman AJ (2019) Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials. J Med Chem 62:2265-2285.

Kraushaar U, Guenther E (2019) Assay Procedures for Compound Testing of hiPSC-Derived Cardiomyocytes Using Multiwell Microelectrode Arrays. Methods Mol Biol 1994:197-208.

Kussauer S, David R, Lemcke H (2019) hiPSCs Derived Cardiac Cells for Drug and Toxicity Screening and Disease Modeling: What Micro- Electrode-Array Analyses Can Tell Us. Cells 8.

Ma S, Ma J, Guo L, Bai J, Mao S, Zhang M (2019) Tongguan capsule-derived herb reduces susceptibility to atrial fibrillation by inhibiting left atrial fibrosis via modulating cardiac fibroblasts. J Cell Mol Med 23:1197-1210.

McAleer CW, Pointon A, Long CJ, Brighton RL, Wilkin BD, Bridges LR, Narasimhan Sriram N, Fabre K, McDougall R, Muse VP, Mettetal JT, Srivastava A, Williams D, Schnepper MT, Roles JL, Shuler ML, Hickman JJ, Ewart L (2019) On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships. Sci Rep 9:9619.

Oleaga C, Jalilvand G, Legters G, Martin C, Ekman G, McAleer CW, Long CJ, Hickman JJ (2019) A human in vitro platform for the evaluation of pharmacology strategies in cardiac ischemia. APL Bioeng 3:036103.

Qian Y, Qian F, Zhang W, Zhao L, Shen M, Ding C, Guo J (2019) Shengjiang Powder ameliorates myocardial injury in septic rats by downregulating the phosphorylation of P38-MAPK. J Biosci 44.

Sun J, Wugeti N, Mahemuti A (2019) Reversal effect of Zhigancao decoction on myocardial fibrosis in a rapid pacing-induced atrial fibrillation model in New Zealand rabbits. J Int Med Res:300060518799819.

Tahrir FG, Gordon J, Feldman AM, Cheung J, Khalili K, Mohseni Ahooyi T (2019) Evidence for the impact of BAG3 on electrophysiological activity of primary culture of neonatal cardiomyocytes. J Cell Physiol.

Wells SP, Waddell HM, Sim CB, Lim SY, Bernasochi GB, Pavlovic D, Kirchhof P, Porrello ER, Delbridge LMD, Bell JR (2019) Cardiomyocyte functional screening - interrogating comparative electrophysiology of high-throughput model cell systems. Am J Physiol Cell Physiol.

Blinova K, Dang Q, Millard D, Smith G, Pierson J, Guo L, Brock M, Lu HR, Kraushaar U, Zeng H, Shi H, Zhang X, Sawada K, Osada T, Kanda Y, Sekino Y, Pang L, Feaster TK, Kettenhofen R, Stockbridge N, Strauss DG, Gintant G (2018) International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment. Cell Reports 24:3582-3592.

Ma J, Ma S, Yin C, Wu H (2018) Shengmai San-derived herbal prevents the development of a vulnerable substrate for atrial fibrillation in a rat model of ischemic heart failure. Biomedicine & Pharmacotherapy 100:156-167.

Millard D, Dang Q, Shi H, Zhang X, Strock C, Kraushaar U, Zeng H, Levesque P, Lu HR, Guillon JM, Wu JC, Li Y, Luerman G, Anson B, Guo L, Clements M, Abassi YA, Ross J, Pierson J, Gintant G (2018) Cross-Site Reliability of Human Induced Pluripotent Stem-Cell Derived Cardiomyocyte Based Safety Assays using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study. Toxicol Sci.

Mulder P, de Korte T, Dragicevic E, Kraushaar U, Printemps R, Vlaming MLH, Braam SR, Valentin JP (2018) Predicting cardiac safety using human induced pluripotent stem cell-derived cardiomyocytes combined with multi-electrode array (MEA) technology: A conference report. J Pharmacol Toxicol Methods 91:36-42.

Abbate E, Boulakia M, Coudière Y, Gerbeau J-F, Zitoun P, Zemzemi N (2017) In silico assessment of the effects of various compounds in MEA/hiPSC-CM assays: Modelling and numerical simulations. In: Inria.

Goineau S, Castagne V (2017) Proarrhythmic risk assessment using conventional and new in vitro assays. Regul Toxicol Pharmacol 88:1-11.

Marczenke M, Piccini I, Mengarelli I, Fell J, Ropke A, Seebohm G, Verkerk AO, Greber B (2017) Cardiac Subtype-Specific Modeling of Kv1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells. Front Physiol 8:469.

Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR, Dunkel L, Lambiase PD, Tinker A (2017) Ajmaline blocks INa and IKr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters. Stem Cell Res 25:233-244.

Pahlavan S, Tousi MS, Ayyari M, Alirezalu A, Ansari H, Saric T, Baharvand H (2017) Effects of hawthorn (Crataegus pentagyna) leaf extract on electrophysiologic properties of cardiomyocytes derived from human cardiac arrhythmia-specific induced pluripotent stem cells. Faseb J.

Stillitano F, Hansen J, Kong C-W, Karakikes I, Funck-Brentano C, Geng L, Scott S, Reynier S, Wu M, Valogne Y, Desseaux C, Salem J-E, Jeziorowska D, Zahr N, Li R, Iyengar R, Hajjar RJ, Hulot J-S (2017) Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells. Elife 6:e19406.

Tertoolen LG, Braam SR, van Meer BJ, Passier R, Mummery CL (2017) Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes. Biochem Biophys Res Commun.

Tixier E, Raphel F, Lombardi D, Gerbeau J-F (2017) Optimal Biomarkers Design for Drug Safety Evaluation Using Microelectrode Array Measurements. In.

Wu J, Wang X, Chung YY, Koh CH, Liu Z, Guo H, Yuan Q, Wang C, Su S, Wei H (2017) L-Type Calcium Channel Inhibition Contributes to the Proarrhythmic Effects of Aconitine in Human Cardiomyocytes. PLoS ONE 12:e0168435.

Zhang L, Meng Q, Zhou X, Li Y, Lu Y, Zhang J, Xing Q, Tang B (2017) Pharmaco-Electrophysiology of Isolated Perfused Rat Heart Assessed with Flexible Microelectrode Arrays. Journal of Veterinary Science & Technology 8.

Ahuja V, Sharma S, Kamboj R (2016) Current Developments in the Use of Human Stem Cell Derived Cardiomyocytes to Examine Drug-induced Cardiotoxicity. In: Issues in Toxicology No. 29, Human Stem Cell Toxicology (Sherley JL, ed).

Cavero I, Guillon JM, Ballet V, Clements M, Gerbeau JF, Holzgrefe H (2016) Comprehensive in vitro Proarrhythmia Assay (CiPA): Pending issues for successful validation and implementation. J Pharmacol Toxicol Methods.

Denning C, Borgdorff V, Crutchley J, Firth KS, George V, Kalra S, Kondrashov A, Hoang MD, Mosqueira D, Patel A, Prodanov L, Rajamohan D, Skarnes WC, Smith JG, Young LE (2016) Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform. Biochim Biophys Acta 1863:1728-1748.

Dhar TGM, Xiao H-Y, Xie J, Lehman-McKeeman LD, Wu D-R, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Warrack B, Shi H, Levesque PC, Zhu JL, Hennan J, Balimane P, Yang Z, Marino AM, Cornelius G, D’Arienzo CJ, Mathur A, Shen DR, Cvijic ME, Salter-Cid L, Barrish JC, Carter PH, Dyckman AJ (2016) Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials. ACS Medicinal Chemistry Letters 7:283-288.

Fang J, Wang Q, Hu N (2016) Micro/Nano Cell Potential Biosensors. In: Micro/Nano Cell and Molecular Sensors (Wang P, Wu C, Hu N, Hsia KJ, eds). Beijing: Springer.

Kuusela J, Kim J, Rasanen E, Aalto-Setala K (2016) The Effects of Pharmacological Compounds on Beat Rate Variations in Human Long QT-Syndrome Cardiomyocytes. Stem Cell Rev.

Malan D, Zhang M, Stallmeyer B, Muller J, Fleischmann BK, Schulze-Bahr E, Sasse P, Greber B (2016) Human iPS cell model of type 3 long QT syndrome recapitulates drug-based phenotype correction. Basic Res Cardiol 111:14.

Masse S, Magtibay K, Jackson N, Asta J, Kusha M, Zhang B, Balachandran R, Radisic M, Deno DC, Nanthakumar K (2016) Resolving Myocardial Activation With Novel Omnipolar Electrograms. Circ Arrhythm Electrophysiol 9:e004107.

Niehoff J, Matzkies M, Nguemo F, Hescheler J, Reppel M (2016) Beat Rate Variability in Murine Embryonic Stem Cell-Derived Cardiomyocytes: Effect of Antiarrhythmic Drugs. Cell Physiol Biochem 38:646-658.

Nozaki Y, Honda Y, Watanabe H, Saiki S, Koyabu K, Itoh T, Nagasawa C, Nakamori C, Nakayama C, Iwasaki H, Suzuki S, Washio I, Takahashi E, Miyamoto K, Yamanishi A, Endo H, Shinozaki J, Nogawa H, Kunimatsu T (2016) CSAHi study: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes -assessment of inter-facility and cells lot-to-lot-variability. Regul Toxicol Pharmacol 77:75-86.

Rast G, Kraushaar U, Buckenmaier S, Ittrich C, Guth BD (2016) Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system selection. Journal of Pharmacological and Toxicological Methods 82:74-82.

Sala L, Bellin M, Mummery CL (2016) Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come? Br J Pharmacol.

Sala L, Yu Z, Ward-van Oostwaard D, van Veldhoven JP, Moretti A, Laugwitz KL, Mummery CL, AP IJ, Bellin M (2016) A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells. EMBO Mol Med 8:1065-1081.

Sallam K, Li Y, Sager PT, Houser SR, Wu JC (2015) Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes. Circ Res 116:1989-2004.

Trantidou T, Terracciano CM, Kontziampasis D, Humphrey EJ, Prodromakis T (2015) Biorealistic cardiac cell culture platforms with integrated monitoring of extracellular action potentials. Sci Rep 5:11067.

Mehta A, Verma V, Nandihalli M, Ramachandra CJ, Sequiera GL, Sudibyo Y, Chung Y, Sun W, Shim W (2014) A systemic evaluation of cardiac differentiation from mRNA reprogrammed human induced pluripotent stem cells. PLoS ONE 9:e103485.

Riedel M, Jou CJ, Lai S, Lux RL, Moreno AP, Spitzer KW, Christians E, Tristani-Firouzi M, Benjamin IJ (2014) Functional and pharmacological analysis of cardiomyocytes differentiated from human peripheral blood mononuclear-derived pluripotent stem cells. Stem Cell Reports 3:131-141.

Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M (2014) Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue. Proc Natl Acad Sci U S A 111:E5383-5392.

Harris K, Aylott M, Cui Y, Louttit JB, McMahon NC, Sridhar A (2013) Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays. Toxicol Sci 134:412-426.

Mandenius CF, Meyer T (2013) HIGH-THROUGHPUT SCREENING ASSAYS TO EVALUATE THE CARDIOTOXIC POTENTIAL OF DRUGS. In: High-Throughput Screening Methods in Toxicity Testing (Steinberg P, ed).

Mehnert JM, Brandenburger M, Grunow B (2013) Electrophysiological Characterization of Spontaneously Contracting Cell Aggregates Obtained from Rainbow Trout Larvae with Multielectrode Arrays. Cell Physiol Biochem 32:1374-1385.

Braam SR, Tertoolen L, Casini S, Matsa E, Lu HR, Teisman A, Passier R, Denning C, Gallacher DJ, Towart R, Mummery CL (2012) Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes. Stem Cell Res 10:48-56.

Daus AW, Layer PG, Thielemann C (2012) A spheroid-based biosensor for the label-free detection of drug-induced field potential alterations. Sensors and Actuators B: Chemical 165:53-58.

Gizurarson S, Shao Y, Miljanovic A, Ramunddal T, Boren J, Bergfeldt L, Omerovic E (2012) Electrophysiological Effects of Lysophosphatidylcholine on HL-1 Cardiomyocytes Assessed with a Microelectrode Array System. Cell Physiol Biochem 30:477-488.

Kujala V, Pekkanen-Mattila M, Aalto-Setala K (2012) Human Pluripotent Stem Cell-Derived Cardiomyocytes: Maturity and Electrophysiology. In: Embryonic Stem Cells - Differentiation and Pluripotent Alternatives (Kallos MS, ed).

Mehta A, Chung YY, Sequiera GL, Wong P, Liew R, Shim W (2012) Pharmaco-Electrophysiology of Viral-Free Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes. Toxicol Sci.

Shao Y, Redfors B, Stahlman M, Tang MS, Miljanovic A, Mollmann H, Troidl C, Szardien S, Hamm C, Nef H, Boren J, Omerovic E (2012) A mouse model reveals an important role for catecholamine-induced lipotoxicity in the pathogenesis of stress-induced cardiomyopathy. Eur J Heart Fail.

Davis RP, van den Berg CW, Casini S, Braam SR, Mummery CL (2011) Pluripotent stem cell models of cardiac disease and their implication for drug discovery and development. Trends Mol Med 17:475-484.

Guo L, Abrams RM, Babiarz JE, Cohen JD, Kameoka S, Sanders MJ, Chiao E, Kolaja KL (2011) Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci 123:281-289.

Itzhaki I, Maizels L, Huber I, Zwi-Dantsis L, Caspi O, Winterstern A, Feldman O, Gepstein A, Arbel G, Hammerman H, Boulos M, Gepstein L (2011) Modelling the long QT syndrome with induced pluripotent stem cells. Nature.

Kraushaar U, Meyer T, Hess D, Gepstein L, C LM, S RB, Guenther E (2011) Cardiac safety pharmacology: from human ether-a-gogo related gene channel block towards induced pluripotent stem cell based disease models. Expert Opin Drug Saf.

Lahti AL, Kujala VJ, Chapman H, Koivisto AP, Pekkanen-Mattila M, Kerkela E, Hyttinen J, Kontula K, Swan H, Conklin BR, Yamanaka S, Silvennoinen O, Aalto-Setala K (2011) Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture. Dis Model Mech.

Mandenius CF, Steel D, Noor F, Meyer T, Heinzle E, Asp J, Arain S, Kraushaar U, Bremer S, Class R, Sartipy P (2011) Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review. J Appl Toxicol.

Matsa E, Rajamohan D, Dick E, Young L, Mellor I, Staniforth A, Denning C (2011) Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation. Eur Heart J.

Mehta A, Chung YY, Ng A, Iskandar F, Atan S, Wei H, Dusting G, Sun W, Wong P, Shim W (2011) Pharmacological response of human cardiomyocytes derived from virus-free induced pluripotent stem cells. Cardiovasc Res 91:577-586.

Natarajan A, Stancescu M, Dhir V, Armstrong C, Sommerhage F, Hickman JJ, Molnar P (2011) Patterned cardiomyocytes on microelectrode arrays as a functional, high information content drug screening platform. Biomaterials 32:4267-4274.

Äänismaa R, Yla-Outinen L, Mikkonen JE, Narkilahti S (2010) Human Pluripotent Stem Cell-Derived Neuronal Networks: Their Electrical Functionality and Usability for Modelling and Toxicology. In: Methodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications (Atwood C, ed).

Asai Y, Tada M, Otsuji TG, Nakatsuji N (2010) Combination of functional cardiomyocytes derived from human stem cells and a highly-efficient microelectrode array system: an ideal hybrid model assay for drug development. Curr Stem Cell Res Ther 5:227-232.

Berdichevski A, Meiry G, Milman F, Reiter I, Sedan O, Eliyahu S, Duffy HS, Youdim MB, Binah O (2010) TVP1022 protects neonatal rat ventricular myocytes against doxorubicin-induced functional derangements. J Pharmacol Exp Ther 332:413-420.

Liang H, Matzkies M, Schunkert H, Tang M, Bonnemeier H, Hescheler J, Reppel M (2010) Human and murine embryonic stem cell-derived cardiomyocytes serve together as a valuable model for drug safety screening. Cell Physiol Biochem 25:459-466.

Bussek A, Wettwer E, Christ T, Lohmann H, Camelliti P, Ravens U (2009) Tissue slices from adult mammalian hearts as a model for pharmacological drug testing. Cell Physiol Biochem 24:527-536.

Heikkila TJ, Yla-Outinen L, Tanskanen JM, Lappalainen RS, Skottman H, Suuronen R, Mikkonen JE, Hyttinen JA, Narkilahti S (2009) Human embryonic stem cell-derived neuronal cells form spontaneously active neuronal networks in vitro. Exp Neurol 218:109-116.

Law JK, Yeung CK, Hofmann B, Ingebrandt S, Rudd JA, Offenhausser A, Chan M (2009) The use of microelectrode array (MEA) to study the protective effects of potassium channel openers on metabolically compromised HL-1 cardiomyocytes. Physiol Meas 30:155-167.

Pfannkuche K, Liang H, Hannes T, Xi J, Fatima A, Nguemo F, Matzkies M, Wernig M, Jaenisch R, Pillekamp F, Halbach M, Schunkert H, Saric T, Hescheler J, Reppel M (2009) Cardiac myocytes derived from murine reprogrammed fibroblasts: intact hormonal regulation, cardiac ion channel expression and development of contractility. Cell Physiol Biochem 24:73-86.

Protas L, Dun W, Jia Z, Lu J, Bucchi A, Kumari S, Chen M, Cohen IS, Rosen MR, Entcheva E, Robinson RB (2009) Expression of skeletal but not cardiac Na+ channel isoform preserves normal conduction in a depolarized cardiac syncytium. Cardiovasc Res 81:528-535.

Dunlop J, Bowlby M, Peri R, Vasilyev D, Arias R (2008) High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology. Nat Rev Drug Discov.

Hofgaard JP, Banach K, Mollerup S, Jorgensen HK, Olesen SP, Holstein-Rathlou NH, Nielsen MS (2008) Phosphatidylinositol-bisphosphate regulates intercellular coupling in cardiac myocytes. Pflugers Arch.

Barac DY, Reisner Y, Silberman M, Naama ZL, Danon A, Salomon O, Shoham M, Shilkrut M, Kostin S, Schaper J, Binah O (2007) Mechanical load induced by glass microspheres releases angiogenic factors from neonatal rat ventricular myocytes cultures and causes arrhythmias. J Cell Mol Med.

Harding SE, Ali NN, Brito-Martins M, Gorelik J (2007) The human embryonic stem cell-derived cardiomyocyte as a pharmacological model. Pharmacol Ther 113:341-353.

Reppel M, Igelmund P, Egert U, Juchelka F, Hescheler J, Drobinskaya I (2007) Effect of cardioactive drugs on action potential generation and propagation in embryonic stem cell-derived cardiomyocytes. Cell Physiol Biochem 19:213-224.

Duan Y, Tang M, Liang H, Hescheler J (2006) Investigation on spontaneous electrical activity of murine embryonic heart using microelectrode arrays. Acta Physiologica Sinica 85:65-70.

Halbach M, Pillekamp F, Brockmeier K, Hescheler J, Muller-Ehmsen J, Reppel M (2006) Ventricular slices of adult mouse hearts--a new multicellular in vitro model for electrophysiological studies. Cell Physiol Biochem 18:1-8.

Jiao Z, De Jesus VR, Iravanian S, Campbell DP, Xu J, Vitali JA, Banach K, Fahrenbach J, Dudley SC, Jr. (2006) A possible mechanism of halocarbon-induced cardiac sensitization arrhythmias. J Mol Cell Cardiol 41:698-705.

Natarajan A, Molnar P, Sieverdes K, Jamshidi A, Hickman JJ (2006) Microelectrode array recordings of cardiac action potentials as a high throughput method to evaluate pesticide toxicity. Toxicol In Vitro 20:375-381.

Rothermel A, Kurz R, Ruffer M, Weigel W, Jahnke HG, Sedello AK, Stepan H, Faber R, Schulze-Forster K, Robitzki AA (2005) Cells on a chip--the use of electric properties for highly sensitive monitoring of blood-derived factors involved in angiotensin II type 1 receptor signalling. Cell Physiol Biochem 16:51-58.

Lu ZJ, Pereverzev A, Liu HL, Weiergraber M, Henry M, Krieger A, Smyth N, Hescheler J, Schneider T (2004) Arrhythmia in isolated prenatal hearts after ablation of the Cav2.3 (alpha1E) subunit of voltage-gated Ca2+ channels. Cell Physiol Biochem 14:11-22.

Meyer T, Boven KH, Gunther E, Fejtl M (2004) Micro-electrode arrays in cardiac safety pharmacology: a novel tool to study QT interval prolongation. Drug Saf 27:763-772.

Meyer T, Leisgen C, Gonser B, Gunther E (2004) QT-screen: high-throughput cardiac safety pharmacology by extracellular electrophysiology on primary cardiac myocytes. Assay Drug Dev Technol 2:507-514.

Reppel M, Boettinger C, Hescheler J (2004) Beta-adrenergic and muscarinic modulation of human embryonic stem cell-derived cardiomyocytes. Cell Physiol Biochem 14:187-196.

Rothermel A, Rüffer M, Urban C, Jahnke HG, Weigel W (2004) A functional cardiomyocyte-based biosensor for Presdiagnostic monitoring: an Angiotensin 2 study. Uni Leipzig:4.

Satin J, Kehat I, Caspi O, Huber I, Arbel G, Itzhaki I, Magyar J, Schroder EA, Perlman I, Gepstein L (2004) Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes. J Physiol 559:479-496.

Banach K, Halbach MD, Hu P, Hescheler J, Egert U (2003) Development of electrical activity in cardiac myocyte aggregates derived from mouse embryonic stem cells. Am J Physiol Heart Circ Physiol 284:H2114-2123.

Stett A, Egert U, Guenther E, Hofmann F, Meyer T, Nisch W, Haemmerle H (2003) Biological application of microelectrode arrays in drug discovery and basic research. Anal Bioanal Chem 377:486-495.