Cardiac myocytes

Hong L, Zhang M, Ly OT, Chen H, Sridhar A, Lambers E, Chalazan B, Youn SW, Maienschein-Cline M, Feferman L, Ong SG, Wu JC, Rehman J, Darbar D (2021) Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation. Stem Cell Reports.

Niehoff J, Matzkies M, Nguemo F, Hescheler J, Reppel M (2021) The influence of melatonin on the heart rhythm - An in vitro simulation with murine embryonic stem cell derived cardiomyocytes. Biomed Pharmacother 136:111245.

Ren X, Gomez JL, Bashar MK, Ji J, Can UI, Chang H-C, Shukla N, Datta S, Zorlutuna P (2021) Cardiac Muscle Cell-Based Coupled Oscillator Network for Collective Computing. Advanced Intelligent Systems n/a:2000253.

Aalders J, Léger L, Van der Meeren L, Van den Vreken N, Skirtach AG, Sinha S, De Backer J, van Hengel J (2020) Effects of fibrillin mutations on the behavior of heart muscle cells in Marfan syndrome. Scientific Reports 10:16756.

Cai H, Li B, Bai A, Huang J, Zhan Y, Sun N, Liang Q, Xu C (2020) Establishing a new human hypertrophic cardiomyopathy-specific model using human embryonic stem cells. Exp Cell Res 387:111736.

Sasserath T, Rumsey JW, McAleer CW, Bridges LR, Long CJ, Elbrecht DH, Schuler F, Roth A, Bertinetti-LaPatki C, Shuler ML, Hickman JJ (2020) Differential Monocyte Actuation in a Three-Organ Functional Innate Immune System-on-a-Chip. Advanced Science n/a:2000323.

Schinner C, Erber BM, Yeruva S, Schlipp A, Rötzer V, Kempf E, Kant S, Leube RE, Mueller TD, Waschke J (2020) Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy. JCI Insight 5.

Shah D (2020) Heart Disease on a Dish. Faculty of Medicine and Health Technology

Stangherlin A, Wong DCS, Barbiero S, Watson JL, Zeng A, Seinkmane E, Chew SP, Beale AD, Hayter EA, Guna A, Inglis AJ, Bartolami E, Matile S, Lequeux N, Pons T, Day JJ, van Ooijen G, Voorhees RM, Bechtold DA, Derivery E, Edgar RS, Newham P, O’Neill JS (2020) Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology. bioRxiv:2020.2005.2028.118398.

van Veldhoven JPD, Campostrini G, van Gessel CJE, Ward-van Oostwaard D, Liu R, Mummery CL, Bellin M, Ijzerman AP (2020) Targeting the Kv11.1 (hERG) channel with allosteric modulators. Synthesis and biological evaluation of three novel series of LUF7346 derivatives. European Journal of Medicinal Chemistry:113033.

Amend N, Thiermann H, Worek F, Wille T (2019) The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM). Toxicol Lett 308:1-6.

Köhler T (2019) Auswirkungen elektromagnetischer Strahlung auf die elektrophysiologischen Eigenschaften neuronaler und kardialer Zellnetzwerke Fachbereich Biologie

Kugler P, Rast G, Guth BD (2019) Comparison of in vitro and computational experiments on the relation of inter-beat interval and duration of repolarization in a specific type of human induced pluripotent stem cell-derived cardiomyocytes. PLoS ONE 14:e0221763.

Li J, Zhang L, Yu L, Minami I, Hörning M, Dong J, Qiao J, Fujimoto N, Shiba Y, Zhao Y, Tang F, Miyagawa S, Chen Y, Sawa Y, Tang C, Liu L (2019) Rapid pacing by circulating traveling waves improves maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring. bioRxiv:717108.

Niehoff J, Matzkies M, Nguemo F, Hescheler J, Reppel M (2019) The Effect of Antiarrhythmic Drugs on the Beat Rate Variability of Human Embryonic and Human Induced Pluripotent Stem Cell Derived Cardiomyocytes. Sci Rep 9:14106.

Oleaga C, Jalilvand G, Legters G, Martin C, Ekman G, McAleer CW, Long CJ, Hickman JJ (2019) A human in vitro platform for the evaluation of pharmacology strategies in cardiac ischemia. APL Bioeng 3:036103.

Pianezzi E, Altomare C, Bolis S, Balbi C, Torre T, Rinaldi A, Camici GG, Barile L, Vassalli G (2019) Role of somatic cell sources in the maturation degree of human induced pluripotent stem cell-derived cardiomyocytes. Biochim Biophys Acta Mol Cell Res:118538.

Simeonov S, Schaffer TE (2019) Ultrafast Imaging of Cardiomyocyte Contractions by Combining Scanning Ion Conductance Microscopy with a Microelectrode Array. Anal Chem.

Tahrir FG, Gordon J, Feldman AM, Cheung J, Khalili K, Mohseni Ahooyi T (2019) Evidence for the impact of BAG3 on electrophysiological activity of primary culture of neonatal cardiomyocytes. J Cell Physiol.

van Meer BJ, Krotenberg A, Sala L, Davis RP, Eschenhagen T, Denning C, Tertoolen LGJ, Mummery CL (2019) Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes. Nat Commun 10:4325.

Vanninen SUM, Kujala V, Porsti I, Aalto-Setala K (2019) A Quantitative Comparison of 12-Lead Electrocardiograms and In Vitro Field Potentials of Stem Cell-Derived Cardiomyocytes. International Journal of Stem Cell Research and Therapeutics.

Wei X, Qin C, Gu C, He C, Yuan Q, Liu M, Zhuang L, Wan H, Wang P (2019) A novel bionic in vitro bioelectronic tongue based on cardiomyocytes and microelectrode array for bitter and umami detection. Biosens Bioelectron 145:111673.

Wells SP, Waddell HM, Sim CB, Lim SY, Bernasochi GB, Pavlovic D, Kirchhof P, Porrello ER, Delbridge LMD, Bell JR (2019) Cardiomyocyte functional screening - interrogating comparative electrophysiology of high-throughput model cell systems. Am J Physiol Cell Physiol.

Yang H, Zhong W, Hamidi MR, Zhou G, Liu C (2019) Functional improvement and maturation of human cardiomyocytes derived from human pluripotent stem cells by barbaloin preconditioning. Acta Biochim Biophys Sin (Shanghai).

Yap L, Wang J-W, Moreno-Moral A, Chong LY, Sun Y, Harmston N, Wang X, Chong SY, Öhman MK, Wei H, Bunte R, Gosh S, Cook S, Hovatta O, de Kleijn DPV, Petretto E, Tryggvason K (2019) Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors. Cell Reports 26:3231-3245.e3239.

Anderson DJ, Kaplan DI, Bell KM, Koutsis K, Haynes JM, Mills RJ, Phelan DG, Qian EL, Leitoguinho AR, Arasaratnam D, Labonne T, Ng ES, Davis RP, Casini S, Passier R, Hudson JE, Porrello ER, Costa MW, Rafii A, Curl CL, Delbridge LM, Harvey RP, Oshlack A, Cheung MM, Mummery CL, Petrou S, Elefanty AG, Stanley EG, Elliott DA (2018) NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network. Nat Commun 9:1373.

Becker BV, Seeger T, Beiert T, Antwerpen M, Palnek A, Port M, Ullmann R (2018) Impact of Ionizing Radiation on Electrophysiological Behavior of Human-induced Ipsc-derived Cardiomyocytes on Multielectrode Arrays. Health Phys 115:21-28.

Cantwell CD, Mohamied Y, Tzortzis KN, Garasto S, Houston C, Chowdhury RA, Ng FS, Bharath AA, Peters NS (2018) Rethinking multiscale cardiac electrophysiology with machine learning and predictive modelling. Comput Biol Med.

Chowdhury RA, Tzortzis KN, Dupont E, Selvadurai S, Perbellini F, Cantwell CD, Ng FS, Simon AR, Terracciano CM, Peters NS (2018) Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices. Sci Rep 8:6947.

Cools J, Jin Q, Yoon E, Alba Burbano D, Luo Z, Cuypers D, Callewaert G, Braeken D, Gracias DH (2018) A Micropatterned Multielectrode Shell for 3D Spatiotemporal Recording from Live Cells. Advanced Science:1700731-n/a.

Dahlmann J, Awad G, Dolny C, Weinert S, Richter K, Fischer KD, Munsch T, Lessmann V, Volleth M, Zenker M, Chen Y, Merkl C, Schnieke A, Baraki H, Kutschka I, Kensah G (2018) Generation of functional cardiomyocytes from rat embryonic and induced pluripotent stem cells using feeder-free expansion and differentiation in suspension culture. PLoS ONE 13:e0192652.

Edwards SL, Zlochiver V, Conrad DB, Vaidyanathan R, Valiquette AM, Joshi-Mukherjee R (2018) A Multiwell Cardiac muGMEA Platform for Action Potential Recordings from Human iPSC-Derived Cardiomyocyte Constructs. Stem Cell Reports.

Fehrentz T, Huber FME, Hartrampf N, Bruegmann T, Frank JA, Fine NHF, Malan D, Danzl JG, Tikhonov DB, Sumser M, Sasse P, Hodson DJ, Zhorov BS, Klöcker N, Trauner D (2018) Optical control of L-type Ca2+ channels using a diltiazem photoswitch. Nature Chemical Biology 14:764-767.

Fleischer S, Jahnke HG, Fritsche E, Girard M, Robitzki AA (2018) Comprehensive human stem cell differentiation in a 2D and 3D mode to cardiomyocytes for long-term cultivation and multiparametric monitoring on a multimodal microelectrode array setup. Biosens Bioelectron 126:624-631.

Ghazizadeh Z, Fattahi F, Mirzaei M, Bayersaikhan D, Lee J, Chae S, Hwang D, Byun K, Tabar MS, Taleahmad S, Mirshahvaladi S, Shabani P, Fonoudi H, Haynes PA, Baharvand H, Aghdami N, Evans T, Lee B, Salekdeh GH (2018) Prospective Isolation of ISL1(+) Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy. Stem Cell Reports 10:848-859.

Golgooni Z, Mirsadeghi S, Soleymani Baghshah M, Ataee P, Baharvand H, Pahlavan S, Rabiee HR (2018) Deep Learning Based Proarrhythmia Analysis Using Field Potentials Recorded from Human Pluripotent Stem Cells Derived Cardiomyocytes. bioRxiv:244442.

Heselich A, Friess JL, Ritter S, Benz NP, Layer PG, Thielemann C (2018) High LET radiation shows no major cellular and functional effects on primary cardiomyocytes in vitro. Life Sci Space Res (Amst) 16:93-100.

Hoque A, Sivakumaran P, Bond ST, Ling NXY, Kong AM, Scott JW, Bandara N, Hernandez D, Liu GS, Wong RCB, Ryan MT, Hausenloy DJ, Kemp BE, Oakhill JS, Drew BG, Pebay A, Lim SY (2018) Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells. Cell Death Discov 4:39.

Krantis A, Tam T, Chichirau A, Kajura K (2018) Cryopreserved Neonatal Rat Ventricular Cardiomyocytes in Long-term Culture Display Normal Morphology and Functional Activity. In.

Kshirsagar P, Martina M, D. JP, Buckenmaier S, Kraushaar U, Chassé T, Fleischer M, Burkhardt CJ (2018) Semitransparent Carbon Microelectrodes for Opto- and Electrophysiology. JOURNAL OF MICROMECHANICS AND MICROENGINEERING.

Millard D, Dang Q, Shi H, Zhang X, Strock C, Kraushaar U, Zeng H, Levesque P, Lu HR, Guillon JM, Wu JC, Li Y, Luerman G, Anson B, Guo L, Clements M, Abassi YA, Ross J, Pierson J, Gintant G (2018) Cross-Site Reliability of Human Induced Pluripotent Stem-Cell Derived Cardiomyocyte Based Safety Assays using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study. Toxicol Sci.

Mulder P, de Korte T, Dragicevic E, Kraushaar U, Printemps R, Vlaming MLH, Braam SR, Valentin JP (2018) Predicting cardiac safety using human induced pluripotent stem cell-derived cardiomyocytes combined with multi-electrode array (MEA) technology: A conference report. J Pharmacol Toxicol Methods 91:36-42.

Oleaga C, Riu A, Rothemund S, Lavado A, McAleer CW, Long CJ, Persaud K, Narasimhan NS, Tran M, Roles J, Carmona-Moran CA, Sasserath T, Elbrecht DH, Kumanchik L, Bridges LR, Martin C, Schnepper MT, Ekman G, Jackson M, Wang YI, Note R, Langer J, Teissier S, Hickman JJ (2018) Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system. Biomaterials 182:176-190.

Pauwelyn T, Stahl R, Mayo L, Zheng X, Lambrechts A, Janssens S, Lagae L, Reumers V, Braeken D (2018) Reflective lens-free imaging on high-density silicon microelectrode arrays for monitoring and evaluation of in vitro cardiac contractility. Biomed Opt Express 9:1827-1841.

Pfeiffer MJ, Quaranta R, Piccini I, Fell J, Rao J, Ropke A, Seebohm G, Greber B (2018) Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES. Nat Commun 9:440.

Schinner C, Erber BM, Yeruva S, Waschke J (2018) Regulation of cardiac myocyte cohesion and gap junctions via desmosomal adhesion. Acta Physiol (Oxf):e13242.

Sottas V, Wahl CM, Trache MC, Bartolf-Kopp M, Cambridge S, Hecker M, Ullrich ND (2018) Improving electrical properties of iPSC-cardiomyocytes by enhancing Cx43 expression. J Mol Cell Cardiol 120:31-41.

Yamauchi K, Li J, Morikawa K, Liu L, Shirayoshi Y, Nakatsuji N, Elliott DA, Hisatome I, Suemori H (2018) Isolation and characterization of ventricular-like cells derived from NKX2-5(eGFP/w) and MLC2v(mCherry/w) double knock-in human pluripotent stem cells. Biochem Biophys Res Commun 495:1278-1284.

Yap L, Wang JW, Moreno-Moral A, Chong LY, Sun Y, Harmston N, Wang X, Chong SY, Ohman MK, Wei H, Bunte R, Ghosh S, Cook S, Hovatta O, de Kleijn DPV, Petretto E, Tryggvason K (2018) In vivo generation of post-infarct mouse cardiac muscle by cardiomyocyte progenitors produced with a reproducible laminin-promoted human stem cell differentiation system. bioRxiv:478883.

Abbate E, Boulakia M, Coudière Y, Gerbeau J-F, Zitoun P, Zemzemi N (2017) In silico assessment of the effects of various compounds in MEA/hiPSC-CM assays: Modelling and numerical simulations. In: Inria.

Can UI, Nagarajan N, Vural DC, Zorlutuna P (2017) Muscle-Cell-Based “Living Diodes”. Advanced Biosystems 1:n/a-n/a.

Eldabah NAM, Nembo EN, Semmler J, Penner M, Molcanyi M, Swelem R, Hassab A, Hescheler J, Nguemo F (2017) Altered Functional Expression of beta-Adrenergic Receptors in Rhesus Monkey Embryonic Stem Cell-derived Cardiomyocytes. Stem Cells Dev.

Giacomelli E, Bellin M, Sala L, van Meer BJ, Tertoolen LGJ, Orlova VV, Mummery CL (2017) Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells. Development 144:1008-1017.

Goineau S, Castagne V (2017) Proarrhythmic risk assessment using conventional and new in vitro assays. Regul Toxicol Pharmacol 88:1-11.

Hulsmann J, Aubin H, Wehrmann A, Lichtenberg A, Akhyari P (2017) The impact of left ventricular stretching in model cultivations with neonatal cardiomyocytes in a whole-heart bioreactor. Biotechnol Bioeng 114:1107-1117.

Kienast R, Handler M, Stoger M, Baumgarten D, Hanser F, Baumgartner C (2017) Modeling hypothermia induced effects for the heterogeneous ventricular tissue from cellular level to the impact on the ECG. PLoS ONE 12:e0182979.

Koh CH, Wu J, Chung YY, Liu Z, Zhang RR, Chong K, Korzh V, Ting S, Oh S, Shim W, Tian HY, Wei H (2017) Electronic supplementary materialIdentification of a Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides. Sci Rep 7:2465.

Kuroda Y, Yuasa S, Watanabe Y, Ito S, Egashira T, Seki T, Hattori T, Ohno S, Kodaira M, Suzuki T, Hashimoto H, Okata S, Tanaka A, Aizawa Y, Murata M, Aiba T, Makita N, Furukawa T, Shimizu W, Kodama I, Ogawa S, Kokubun N, Horigome H, Horie M, Kamiya K, Fukuda K (2017) Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes. Biochemistry and Biophysics Reports 9:245-256.

Kuusela J, Larsson K, Shah D, Prajapati C, Aalto-Setala K (2017) Low extracellular potassium prolongs repolarization and evokes early afterdepolarization in human induced pluripotent stem cell-derived cardiomyocytes. Biol Open 6:777-784.

Li B, Yang H, Wang X, Zhan Y, Sheng W, Cai H, Xin H, Liang Q, Zhou P, Lu C, Qian R, Chen S, Yang P, Zhang J, Shou W, Huang G, Liang P, Sun N (2017) Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes. Stem Cell Res Ther 8:202.

Lin ZC, McGuire AF, Burridge PW, Matsa E, Lou H-Y, Wu JC, Cui B (2017) Accurate nanoelectrode recording of human pluripotent stem cell-derived cardiomyocytes for assaying drugs and modeling disease. Microsystems & Nanoengineering 3:16080.

Marcoux D, Xiao H-Y, Murali Dhar TG, Xie J, Lehman-McKeeman LD, Wu D-R, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Shi H, Levesque PC, Sun H, Yang Z, Marino AM, Cornelius G, D'Arienzo CJ, Gupta A, Pragalathan B, Rampulla R, Mathur A, Shen DR, Cvijic ME, Salter-Cid L, Lombardo LJ, Carter PH, Dyckman AJ (2017) Identification of potent tricyclic prodrug S1P1 receptor modulators. MedChemComm.

Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR, Dunkel L, Lambiase PD, Tinker A (2017) Ajmaline blocks INa and IKr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters. Stem Cell Res 25:233-244.

Pahlavan S, Tousi MS, Ayyari M, Alirezalu A, Ansari H, Saric T, Baharvand H (2017) Effects of hawthorn (Crataegus pentagyna) leaf extract on electrophysiologic properties of cardiomyocytes derived from human cardiac arrhythmia-specific induced pluripotent stem cells. Faseb J.

Park S-J, Kim K-H, Jeon W-Y, Seo J, Han J-M, Kim J-S, Chung H-M, Lee J-H, Moon S-H, Kim H-H (2017) Enzyme catalyzed electrostimulation of human embryonic stem cell-derived cardiomyocytes influence contractility and synchronization. Biochemical Engineering Journal 123:95-109.

Protze SI, Liu J, Nussinovitch U, Ohana L, Backx PH, Gepstein L, Keller GM (2017) Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker. Nat Biotechnol 35:56-68.

Sala L, Ward-van Oostwaard D, Tertoolen LGJ, Mummery CL, Bellin M (2017) Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs). JoVE:e55587.

Schürlein S, Al Hijailan R, Weigel T, Kadari A, Rücker C, Edenhofer F, Walles H, Hansmann J (2017) Generation of a Human Cardiac Patch Based on a Reendothelialized Biological Scaffold (BioVaSc). Advanced Biosystems 1:1600005-n/a.

Shen N, Knopf A, Westendorf C, Kraushaar U, Riedl J, Bauer H, Pöschel S, Layland SL, Holeiter M, Knolle S, Brauchle E, Nsair A, Hinderer S, Schenke-Layland K (2017) Steps toward Maturation of Embryonic Stem Cell-Derived Cardiomyocytes by Defined Physical Signals. Stem Cell Reports 9:122-135.

Smit NW, Cócera Ortega L, Végh AMD, Meijborg VMF, Smits AM, Klerk M, Tijsen AJM, Tan HL, Goumans M-JHT, Boink GJJ, Coronel R (2017) Human Cardiomyocyte Progenitor Cells in Co-culture with Rat Cardiomyocytes Form a Pro-arrhythmic Substrate: Evidence for Two Different Arrhythmogenic Mechanisms. Frontiers in Physiology 8.

Smit NW, Ten Sande JN, Parvizi M, van Amersfoorth SCM, Plantinga JA, van Spreuwel-Goossens C, van Dongen E, van Dessel P, Kluijtmans S, Meijborg VMF, de Bakker JMT, Harmsen MC, Coronel R (2017) Recombinant human collagen-based microspheres mitigate cardiac conduction slowing induced by adipose tissue-derived stromal cells. PLoS ONE 12:e0183481.

Ten Sande JN, Smit NW, Parvizi M, van Amersfoorth SC, Plantinga JA, van Dessel PF, de Bakker JM, Harmsen MC, Coronel R (2017) Differential Mechanisms of Myocardial Conduction Slowing by Adipose Tissue-Derived Stromal Cells Derived from Different Species. Stem Cells Transl Med 6:22-30.

Tertoolen LG, Braam SR, van Meer BJ, Passier R, Mummery CL (2017) Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes. Biochem Biophys Res Commun.

Tixier E, Raphel F, Lombardi D, Gerbeau J-F (2017) Optimal Biomarkers Design for Drug Safety Evaluation Using Microelectrode Array Measurements. In.

Vuorenpaa H, Penttinen K, Heinonen T, Pekkanen-Mattila M, Sarkanen JR, Ylikomi T, Aalto-Setala K (2017) Maturation of human pluripotent stem cell derived cardiomyocytes is improved in cardiovascular construct. Cytotechnology.

Wu J, Wang X, Chung YY, Koh CH, Liu Z, Guo H, Yuan Q, Wang C, Su S, Wei H (2017) L-Type Calcium Channel Inhibition Contributes to the Proarrhythmic Effects of Aconitine in Human Cardiomyocytes. PLoS ONE 12:e0168435.

Zhu H, Scharnhorst KS, Stieg AZ, Gimzewski JK, Minami I, Nakatsuji N, Nakano H, Nakano A (2017) Two dimensional electrophysiological characterization of human pluripotent stem cell-derived cardiomyocyte system. Sci Rep 7:43210.

Denning C, Borgdorff V, Crutchley J, Firth KS, George V, Kalra S, Kondrashov A, Hoang MD, Mosqueira D, Patel A, Prodanov L, Rajamohan D, Skarnes WC, Smith JG, Young LE (2016) Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform. Biochim Biophys Acta 1863:1728-1748.

Dhar TGM, Xiao H-Y, Xie J, Lehman-McKeeman LD, Wu D-R, Dabros M, Yang X, Taylor TL, Zhou XD, Heimrich EM, Thomas R, McIntyre KW, Warrack B, Shi H, Levesque PC, Zhu JL, Hennan J, Balimane P, Yang Z, Marino AM, Cornelius G, D’Arienzo CJ, Mathur A, Shen DR, Cvijic ME, Salter-Cid L, Barrish JC, Carter PH, Dyckman AJ (2016) Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials. ACS Medicinal Chemistry Letters 7:283-288.

Fang X, Poulsen RR, Wang-Hu J, Shi O, Calvo NS, Simmons CS, Rivkees SA, Wendler CC (2016) Knockdown of DNA methyltransferase 3a alters gene expression and inhibits function of embryonic cardiomyocytes. Faseb J 30:3238-3255.

Feiner R, Engel L, Fleischer S, Malki M, Gal I, Shapira A, Shacham-Diamand Y, Dvir T (2016) Engineered hybrid cardiac patches with multifunctional electronics for online monitoring and regulation of tissue function. Nat Mater.

Hernandez D, Millard R, Sivakumaran P, Wong RC, Crombie DE, Hewitt AW, Liang H, Hung SS, Pebay A, Shepherd RK, Dusting GJ, Lim SY (2016) Electrical Stimulation Promotes Cardiac Differentiation of Human Induced Pluripotent Stem Cells. Stem Cells Int 2016:1718041.

Kuusela J, Kim J, Rasanen E, Aalto-Setala K (2016) The Effects of Pharmacological Compounds on Beat Rate Variations in Human Long QT-Syndrome Cardiomyocytes. Stem Cell Rev.

Kuusela J, Kujala VJ, Kiviaho A, Ojala M, Swan H, Kontula K, Aalto-Setala K (2016) Effects of cardioactive drugs on human induced pluripotent stem cell derived long QT syndrome cardiomyocytes. Springerplus 5:234.

Li J, Minami I, Yu L, Tsuji K, Nakajima M, Qiao J, Suzuki M, Shimono K, Nakatsuji N, Kotera H, Liu L, Chen Y (2016) Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers. Stem Cells Int 2016:2634013.

Masse S, Magtibay K, Jackson N, Asta J, Kusha M, Zhang B, Balachandran R, Radisic M, Deno DC, Nanthakumar K (2016) Resolving Myocardial Activation With Novel Omnipolar Electrograms. Circ Arrhythm Electrophysiol 9:e004107.

Matschke V, Piccini I, Schubert J, Wrobel E, Lang F, Matschke J, Amedonu E, Meuth SG, Strunker T, Strutz-Seebohm N, Greber B, Scherkenbeck J, Seebohm G (2016) The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels. Cell Physiol Biochem 40:1549-1558.

Niehoff J, Matzkies M, Nguemo F, Hescheler J, Reppel M (2016) Beat Rate Variability in Murine Embryonic Stem Cell-Derived Cardiomyocytes: Effect of Antiarrhythmic Drugs. Cell Physiol Biochem 38:646-658.

Nozaki Y, Honda Y, Watanabe H, Saiki S, Koyabu K, Itoh T, Nagasawa C, Nakamori C, Nakayama C, Iwasaki H, Suzuki S, Washio I, Takahashi E, Miyamoto K, Yamanishi A, Endo H, Shinozaki J, Nogawa H, Kunimatsu T (2016) CSAHi study: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes -assessment of inter-facility and cells lot-to-lot-variability. Regul Toxicol Pharmacol 77:75-86.

Okata S, Yuasa S, Suzuki T, Ito S, Makita N, Yoshida T, Li M, Kurokawa J, Seki T, Egashira T, Aizawa Y, Kodaira M, Motoda C, Yozu G, Shimojima M, Hayashiji N, Hashimoto H, Kuroda Y, Tanaka A, Murata M, Aiba T, Shimizu W, Horie M, Kamiya K, Furukawa T, Fukuda K (2016) Embryonic type Na+ channel beta-subunit, SCN3B masks the disease phenotype of Brugada syndrome. Sci Rep 6:34198.

Rast G, Kraushaar U, Buckenmaier S, Ittrich C, Guth BD (2016) Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system selection. Journal of Pharmacological and Toxicological Methods 82:74-82.

Sala L, Bellin M, Mummery CL (2016) Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come? Br J Pharmacol.

Sala L, Yu Z, Ward-van Oostwaard D, van Veldhoven JP, Moretti A, Laugwitz KL, Mummery CL, AP IJ, Bellin M (2016) A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells. EMBO Mol Med 8:1065-1081.

Trieschmann J, Bettin D, Haustein M, Köster A, Molcanyi M, Halbach M, Hanna M, Fouad M, Brockmeier K, Hescheler J, Pfannkuche K, Hannes T (2016) The Interaction between Adult Cardiac Fibroblasts and Embryonic Stem Cell-Derived Cardiomyocytes Leads to Proarrhythmic Changes in In Vitro Cocultures. Stem Cells International 2016:12.

Asakura K, Hayashi S, Ojima A, Taniguchi T, Miyamoto N, Nakamori C, Nagasawa C, Kitamura T, Osada T, Honda Y, Kasai C, Ando H, Kanda Y, Sekino Y, Sawada K (2015) Improvement of acquisition and analysis methods in multi-electrode array experiments with iPS cell-derived cardiomyocytes. J Pharmacol Toxicol Methods.

Friedrichs S, Malan D, Voss Y, Sasse P (2015) Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy Journal of Clinical Medicine 4:102-123.

Friess JL, Heselich A, Ritter S, Haber A, Kaiser N, Layer PG, Thielemann C (2015) Electrophysiologic and cellular characteristics of cardiomyocytes after X-ray irradiation. Mutat Res 777:1-10.

Hannes T, Wolff M, Doss MX, Pfannkuche K, Haustein M, Muller-Ehmsen J, Sachinidis A, Hescheler J, Khalil M, Halbach M (2015) Electrophysiological characteristics of embryonic stem cell-derived cardiomyocytes are cell line-dependent. Cell Physiol Biochem 35:305-314.

Nussinovitch U, Gepstein L (2015) Optogenetics for suppression of cardiac electrical activity in human and rat cardiomyocyte cultures. Neurophotonics 2:031204.

Pisano F, Altomare C, Cervio E, Barile L, Rocchetti M, Ciuffreda MC, Malpasso G, Copes F, Mura M, Danieli P, Viarengo G, Zaza A, Gnecchi M (2015) Combination of miRNA499 and miRNA133 exerts a synergic effect on cardiac differentiation. Stem Cells 33:1187-1199.

Rast G, Weber J, Disch C, Schuck E, Ittrich C, Guth BD (2015) An integrated platform for simultaneous multi-well field potential recording and Fura-2-based calcium transient ratiometry in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. J Pharmacol Toxicol Methods.

Sallam K, Li Y, Sager PT, Houser SR, Wu JC (2015) Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes. Circ Res 116:1989-2004.

Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, Franklin S, Fiji HD, Wang K, Zhu H, Tian C, Lin B, Nakano H, Ehrlich A, Nakai J, Stieg AZ, Gimzewski JK, Nakano A, Goldhaber JI, Vondriska TM, Hajnoczky G, Kwon O, Chen JN (2015) Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. Elife 4.

Stancescu M, Molnar P, McAleer CW, McLamb W, Long CJ, Oleaga C, Prot JM, Hickman JJ (2015) A phenotypic in vitro model for the main determinants of human whole heart function. Biomaterials 60:20-30.

Trantidou T, Terracciano CM, Kontziampasis D, Humphrey EJ, Prodromakis T (2015) Biorealistic cardiac cell culture platforms with integrated monitoring of extracellular action potentials. Sci Rep 5:11067.

Zhang M, Schulte JS, Heinick A, Piccini I, Rao J, Quaranta R, Zeuschner D, Malan D, Kim KP, Ropke A, Sasse P, Arauzo-Bravo M, Seebohm G, Scholer H, Fabritz L, Kirchhof P, Muller FU, Greber B (2015) Universal cardiac induction of human pluripotent stem cells in two and three-dimensional formats: implications for in vitro maturation. Stem Cells 33:1456-1469.

Ben-Ari M, Schick R, Barad L, Novak A, Ben-Ari E, Lorber A, Itskovitz-Eldor J, Rosen MR, Weissman A, Binah O (2014) From beat rate variability in induced pluripotent stem cell-derived pacemaker cells to heart rate variability in human subjects. Heart Rhythm.

Bingen BO, Engels MC, Schalij MJ, Jangsangthong W, Neshati Z, Feola I, Ypey DL, Askar SF, Panfilov AV, Pijnappels DA, de Vries AA (2014) Light-induced termination of spiral wave arrhythmias by optogenetic engineering of atrial cardiomyocytes. Cardiovasc Res 104:194-205.

Kienast R, Stoger M, Handler M, Hanser F, Baumgartner C (2014) Alterations of field potentials in isotropic cardiomyocyte cell layers induced by multiple endogenous pacemakers under normal and hypothermal conditions. Am J Physiol Heart Circ Physiol 307:H1013-1023.

Lin ZC, Xie C, Osakada Y, Cui Y, Cui B (2014) Iridium oxide nanotube electrodes for sensitive and prolonged intracellular measurement of action potentials. Nat Commun 5:3206.

Mehta A, Verma V, Nandihalli M, Ramachandra CJ, Sequiera GL, Sudibyo Y, Chung Y, Sun W, Shim W (2014) A systemic evaluation of cardiac differentiation from mRNA reprogrammed human induced pluripotent stem cells. PLoS ONE 9:e103485.

Riedel M, Jou CJ, Lai S, Lux RL, Moreno AP, Spitzer KW, Christians E, Tristani-Firouzi M, Benjamin IJ (2014) Functional and pharmacological analysis of cardiomyocytes differentiated from human peripheral blood mononuclear-derived pluripotent stem cells. Stem Cell Reports 3:131-141.

Xu B, Binczak S, Jacquir S, Pont O, Yahia H (2014) Complexity analysis of experimental cardiac arrhythmia. In: 2014 IEEE Region 10 Technical Symposium (TENSYMP). Kuala Lumpur.

Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M (2014) Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue. Proc Natl Acad Sci U S A 111:E5383-5392.

Caspi O, Huber I, Gepstein A, Arbel G, Maizels L, Boulos M, Gepstein L (2013) Modeling of arrhythmogenic right ventricular cardiomyopathy with human induced pluripotent stem cells. Circ Cardiovasc Genet 6:557-568.

Harris K, Aylott M, Cui Y, Louttit JB, McMahon NC, Sridhar A (2013) Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays. Toxicol Sci 134:412-426.

Kapoor N, Liang W, Marban E, Cho HC (2013) Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18. Nat Biotechnol 31:54-62.

Khan JM, Lyon AR, Harding SE (2013) The case for induced pluripotent stem cell-derived cardiomyocytes in pharmacological screening. Br J Pharmacol 169:304-317.

Lehmann M, Nguemo F, Wagh V, Pfannkuche K, Hescheler J, Reppel M (2013) Evidence for a critical role of catecholamines for cardiomyocyte lineage commitment in murine embryonic stem cells. PLoS ONE 8:e70913.

Mandenius CF, Meyer T (2013) HIGH-THROUGHPUT SCREENING ASSAYS TO EVALUATE THE CARDIOTOXIC POTENTIAL OF DRUGS. In: High-Throughput Screening Methods in Toxicity Testing (Steinberg P, ed).

Matsa E, Dixon JE, Medway C, Georgiou O, Patel MJ, Morgan K, Kemp PJ, Staniforth A, Mellor I, Denning C (2013) Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes. Eur Heart J.

Mureli S, Gans CP, Bare DJ, Geenen DL, Kumar NM, Banach K (2013) Mesenchymal stem cells improve cardiac conduction by upregulation of connexin 43 through paracrine signaling. Am J Physiol Heart Circ Physiol 304:H600-609.

Ohno Y, Yuasa S, Egashira T, Seki T, Hashimoto H, Tohyama S, Saito Y, Kunitomi A, Shimoji K, Onizuka T, Kageyama T, Yae K, Tanaka T, Kaneda R, Hattori F, Murata M, Kimura K, Fukuda K (2013) Distinct iPS Cells Show Different Cardiac Differentiation Efficiency. In: Hindawi Publishing Corporation Stem Cells International.

Pradhapan P, Kuusela J, Viik J, Aalto-Setala K, Hyttinen J (2013) Cardiomyocyte MEA data analysis (CardioMDA)--a novel field potential data analysis software for pluripotent stem cell derived cardiomyocytes. PLoS ONE 8:e73637.

Rubach M, Adelmann R, Haustein M, Drey F, Pfannkuche K, Xiao B, Koester A, Udink Ten Cate FE, Choi YH, Neef K, Fatima A, Hannes T, Pillekamp F, Hescheler J, Saric T, Brockmeier K, Khalil M (2013) Mesenchymal Stem Cells and their Conditioned Medium Improve Integration of purified Induced Pluripotent Stem-Cell Derived Cardiomyocyte Clusters into Myocardial Tissue. Stem Cells Dev.

Xu B, Jacquir S, Laurent G, Bilbault JM, Binczak S (2013) Phase space reconstruction of an experimental model of cardiac field potential in normal and arrhythmic conditions. In: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

Braam SR, Tertoolen L, Casini S, Matsa E, Lu HR, Teisman A, Passier R, Denning C, Gallacher DJ, Towart R, Mummery CL (2012) Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes. Stem Cell Res 10:48-56.

Daus AW, Layer PG, Thielemann C (2012) A spheroid-based biosensor for the label-free detection of drug-induced field potential alterations. Sensors and Actuators B: Chemical 165:53-58.

Enochson L, Sandstedt J, Strandberg H, Emanuelsson C, Ornberg A, Lindahl A, Karlsson C (2012) Triphasic and quadriphasic waveforms are superior to biphasic waveforms for synchronized beating of cardiomyocytes. J Electrocardiol.

Fendyur A, Spira ME (2012) Toward on-chip, in-cell recordings from cultured cardiomyocytes by arrays of gold mushroom-shaped microelectrodes. Front Neuroeng 5:21.

Gizurarson S, Shao Y, Miljanovic A, Ramunddal T, Boren J, Bergfeldt L, Omerovic E (2012) Electrophysiological Effects of Lysophosphatidylcholine on HL-1 Cardiomyocytes Assessed with a Microelectrode Array System. Cell Physiol Biochem 30:477-488.

Kujala K, Ahola A, Pekkanen-Mattila M, Ikonen L, Kerkela E, Hyttinen J, Aalto-Setala K (2012) Electrical Field Stimulation with a Novel Platform: Effect on Cardiomyocyte Gene Expression but not on Orientation. Int J Biomed Sci 8:109-120.

Kujala V, Pekkanen-Mattila M, Aalto-Setala K (2012) Human Pluripotent Stem Cell-Derived Cardiomyocytes: Maturity and Electrophysiology. In: Embryonic Stem Cells - Differentiation and Pluripotent Alternatives (Kallos MS, ed).

Ma Z, Liu Q, Liu H, Yang H, Yun JX, Eisenberg C, Borg TK, Xu M, Gao BZ (2012) Laser-patterned stem-cell bridges in a cardiac muscle model for on-chip electrical conductivity analyses. Lab Chip 12:566-573.

Mandel Y, Weissman A, Schick R, Barad L, Novak A, Meiry G, Goldberg S, Lorber A, Rosen MR, Itskovitz-Eldor J, Binah O (2012) Human embryonic and induced pluripotent stem cell-derived cardiomyocytes exhibit beat rate variability and power-law behavior. Circulation 125:883-893.

Mehta A, Chung YY, Sequiera GL, Wong P, Liew R, Shim W (2012) Pharmaco-Electrophysiology of Viral-Free Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes. Toxicol Sci.

Nick C, Joshi R, Schneider JJ, Thielemann C (2012) Three-dimensional carbon nanotube electrodes for extracellular recording of cardiac myocytes. Biointerphases 7:58.

Sequiera GL, Mehta A, Ooi TH, Shim W (2012) Ontogenic Development of Cardiomyocytes Derived from Transgene-Free Human Induced Pluripotent Stem Cells and Its Homology with Human Heart. Life Sci.

Shao Y, Redfors B, Stahlman M, Tang MS, Miljanovic A, Mollmann H, Troidl C, Szardien S, Hamm C, Nef H, Boren J, Omerovic E (2012) A mouse model reveals an important role for catecholamine-induced lipotoxicity in the pathogenesis of stress-induced cardiomyopathy. Eur J Heart Fail.

Zwi-Dantsis L, Huber I, Habib M, Winterstern A, Gepstein A, Arbel G, Gepstein L (2012) Derivation and cardiomyocyte differentiation of induced pluripotent stem cells from heart failure patients. Eur Heart J.

Abilez OJ, Wong J, Prakash R, Deisseroth K, Zarins CK, Kuhl E (2011) Multiscale computational models for optogenetic control of cardiac function. Biophys J 101:1326-1334.

Askar SF, Ramkisoensing AA, Schalij MJ, Bingen BO, Swildens J, van der Laarse A, Atsma DE, de Vries AA, Ypey DL, Pijnappels DA (2011) Antiproliferative treatment of myofibroblasts prevents arrhythmias in vitro by limiting myofibroblast-induced depolarization. Cardiovasc Res 90:295-304.

Bax NA, Pijnappels DA, van Oorschot AA, Winter EM, de Vries AA, van Tuyn J, Braun J, Maas S, Schalij MJ, Atsma DE, Goumans MJ, Gittenberger-de Groot AC (2011) Epithelial-to-mesenchymal transformation alters electrical conductivity of human epicardial cells. J Cell Mol Med 15:2675-2683.

Daus AW, Goldhammer M, Layer PG, Thielemann C (2011) Electromagnetic exposure of scaffold-free three-dimensional cell culture systems. Bioelectromagnetics 32:351-359.

Elliott DA, Braam SR, Koutsis K, Ng ES, Jenny R, Lagerqvist EL, Biben C, Hatzistavrou T, Hirst CE, Yu QC, Skelton RJ, Ward-van Oostwaard D, Lim SM, Khammy O, Li X, Hawes SM, Davis RP, Goulburn AL, Passier R, Prall OW, Haynes JM, Pouton CW, Kaye DM, Mummery CL, Elefanty AG, Stanley EG (2011) NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes. Nat Methods 8:1037-1040.

Grunow B, Wenzel J, Terlau H, Langner S, Gebert M, Kruse C (2011) In vitro developed spontaneously contracting cardiomyocytes from rainbow trout as a model system for human heart research. Cell Physiol Biochem 27:1-12.

Guo L, Abrams RM, Babiarz JE, Cohen JD, Kameoka S, Sanders MJ, Chiao E, Kolaja KL (2011) Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci 123:281-289.

Guo L, Qian JY, Abrams R, Tang HM, Weiser T, Sanders MJ, Kolaja KL (2011) The electrophysiological effects of cardiac glycosides in human iPSC-derived cardiomyocytes and in guinea pig isolated hearts. Cell Physiol Biochem 27:453-462.

Hofshi A, Itzhaki I, Gepstein A, Arbel G, Gross GJ, Gepstein L (2011) A combined gene and cell therapy approach for restoration of conduction. Heart Rhythm 8:121-130.

Itzhaki I, Maizels L, Huber I, Zwi-Dantsis L, Caspi O, Winterstern A, Feldman O, Gepstein A, Arbel G, Hammerman H, Boulos M, Gepstein L (2011) Modelling the long QT syndrome with induced pluripotent stem cells. Nature.

Jacquir S, Binczak S, Xu B, Laurent G, Vandroux D, Athias P, Bilbault JM (2011) INVESTIGATION OF MICRO SPIRAL WAVES AT CELLULAR LEVEL USING A MICROELECTRODE ARRAYS TECHNOLOGY. International Journal of Bifurcation and Chaos 21 1:209-223.

Kapoor N, Galang G, Marban E, Cho HC (2011) Transcriptional suppression of Connexin43 by Tbx18 undermines cell-cell electrical coupling in postnatal cardiomyocytes. J Biol Chem.

Kraushaar U, Meyer T, Hess D, Gepstein L, C LM, S RB, Guenther E (2011) Cardiac safety pharmacology: from human ether-a-gogo related gene channel block towards induced pluripotent stem cell based disease models. Expert Opin Drug Saf.

Kujala VJ, Jimenez ZC, Vaisanen J, Tanskanen JM, Kerkela E, Hyttinen J, Aalto-Setala K (2011) Averaging in vitro cardiac field potential recordings obtained with microelectrode arrays. Comput Methods Programs Biomed.

Kujala VJ, Pekkanen-Mattila M, Aalto-Setala K (2011) Human Pluripotent Stem Cell-Derived Cardiomyocytes: Maturity and Electrophysiology. In: Embryonic Stem Cells - Differentiation and Pluripotent Alternatives (Kallos MS, ed).

Lahti AL, Kujala VJ, Chapman H, Koivisto AP, Pekkanen-Mattila M, Kerkela E, Hyttinen J, Kontula K, Swan H, Conklin BR, Yamanaka S, Silvennoinen O, Aalto-Setala K (2011) Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture. Dis Model Mech.

Mandenius CF, Steel D, Noor F, Meyer T, Heinzle E, Asp J, Arain S, Kraushaar U, Bremer S, Class R, Sartipy P (2011) Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review. J Appl Toxicol.

Matsa E, Rajamohan D, Dick E, Young L, Mellor I, Staniforth A, Denning C (2011) Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation. Eur Heart J.

Mehta A, Chung YY, Ng A, Iskandar F, Atan S, Wei H, Dusting G, Sun W, Wong P, Shim W (2011) Pharmacological response of human cardiomyocytes derived from virus-free induced pluripotent stem cells. Cardiovasc Res 91:577-586.

Natarajan A, Stancescu M, Dhir V, Armstrong C, Sommerhage F, Hickman JJ, Molnar P (2011) Patterned cardiomyocytes on microelectrode arrays as a functional, high information content drug screening platform. Biomaterials 32:4267-4274.

Pekkanen-Mattila M, Kerkela E, Aalto-Setala K (2011) Differentiation, Characterization and Applications of Human Embryonic Stem Cell – Derived Cardiomyocytes. In: Embryonic Stem Cells: The Hormonal Regulation of Pluripotency and Embryogenesis (Altwoos C, ed).

Ritner C, Wong SS, King FW, Mihardja SS, Liszewski W, Erle DJ, Lee RJ, Bernstein HS (2011) An engineered cardiac reporter cell line identifies human embryonic stem cell-derived myocardial precursors. PLoS ONE 6:e16004.

Saenz Cogollo JF, Tedesco M, Martinoia S, Raiteri R (2011) A new integrated system combining atomic force microscopy and micro-electrode array for measuring the mechanical properties of living cardiac myocytes. Biomed Microdevices 13:613-621.

Asai Y, Tada M, Otsuji TG, Nakatsuji N (2010) Combination of functional cardiomyocytes derived from human stem cells and a highly-efficient microelectrode array system: an ideal hybrid model assay for drug development. Curr Stem Cell Res Ther 5:227-232.

Berdichevski A, Meiry G, Milman F, Reiter I, Sedan O, Eliyahu S, Duffy HS, Youdim MB, Binah O (2010) TVP1022 protects neonatal rat ventricular myocytes against doxorubicin-induced functional derangements. J Pharmacol Exp Ther 332:413-420.

Braam SR (2010) Human embryonic stem cells - Advancing biology and cardiogenesis towards functional applications

Chan YC, Tse HF, Siu CW, Wang K, Li RA (2010) Automaticity and conduction properties of bio-artificial pacemakers assessed in an in vitro monolayer model of neonatal rat ventricular myocytes. Europace.

Danielsson C (2010) Role of the HERG channel in arrhythmia and teratogenicity.

Danon A, Zeevi-Levin N, Pinkovich DY, Michaeli T, Berkovich A, Flugelman M, Eldar YC, Rosen MR, Binah O (2010) Hypoxia causes connexin 43 internalization in neonatal rat ventricular myocytes. Gen Physiol Biophys 29:222-233.

Gupta MK, Illich DJ, Gaarz A, Matzkies M, Nguemo F, Pfannkuche K, Liang H, Classen S, Reppel M, Schultze JL, Hescheler J, Saric T (2010) Global transcriptional profiles of beating clusters derived from human induced pluripotent stem cells and embryonic stem cells are highly similar. BMC Dev Biol 10:98.

Liang H, Matzkies M, Schunkert H, Tang M, Bonnemeier H, Hescheler J, Reppel M (2010) Human and murine embryonic stem cell-derived cardiomyocytes serve together as a valuable model for drug safety screening. Cell Physiol Biochem 25:459-466.

Meyer T, Stuerz K, Guenther E, Edamura M, Kraushaar U (2010) Cardiac slices as a predictive tool for arrhythmogenic potential of drugs and chemicals. Expert Opin Drug Metab Toxicol 6:1461-1475.

Novak A, Shtrichman R, Germanguz I, Segev H, Zeevi-Levin N, Fishman B, Mandel YE, Barad L, Domev H, Kotton D, Mostoslavsky G, Binah O, Itskovitz-Eldor J (2010) Enhanced reprogramming and cardiac differentiation of human keratinocytes derived from plucked hair follicles, using a single excisable lentivirus. Cell Reprogram 12:665-678.

Xiao YF (2010) Multi-channel System for Analysis of Cardiac Rhythmicity and Conductivity In Vitro. In: Cardiac Electrophysiology Methods and Models (Sigg DC, ed).

Braam SR, Passier R, Mummery CL (2009) Cardiomyocytes from human pluripotent stem cells in regenerative medicine and drug discovery. Trends Pharmacol Sci 30:536-545.

Braam SR, Tertoolen L, van de Stolpe A, Meyer T, Passier R, Mummery CL (2009) Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes. Stem Cell Res.

Dawson JE, Boisvenue S, Skerjanc IS, Griffith M (2009) A P19 Cardiac Cell Line as a Model for Evaluating Cardiac Tissue Engineering Biomaterials. The Open Tissue Engineering and Regenerative Medicine Journal 2.

Genead R, Danielsson C, Wardell E, Kjaeldgaard A, Westgren M, Sundstrom E, Franco-Cereceda A, Sylven C, Grinnemo KH (2009) Early first trimester human embryonic cardiac Islet-1 progenitor cells and cardiomyocytes: Immunohistochemical and electrophysiological characterization. Stem Cell Res.

Law JK, Yeung CK, Hofmann B, Ingebrandt S, Rudd JA, Offenhausser A, Chan M (2009) The use of microelectrode array (MEA) to study the protective effects of potassium channel openers on metabolically compromised HL-1 cardiomyocytes. Physiol Meas 30:155-167.

Pekkanen-Mattila M, Kerkela E, Tanskanen JM, Pietila M, Pelto-Huikko M, Hyttinen J, Skottman H, Suuronen R, Aalto-Setala K (2009) Substantial variation in the cardiac differentiation of human embryonic stem cell lines derived and propagated under the same conditions--a comparison of multiple cell lines. Ann Med 41:360-370.

Pfannkuche K, Liang H, Hannes T, Xi J, Fatima A, Nguemo F, Matzkies M, Wernig M, Jaenisch R, Pillekamp F, Halbach M, Schunkert H, Saric T, Hescheler J, Reppel M (2009) Cardiac myocytes derived from murine reprogrammed fibroblasts: intact hormonal regulation, cardiac ion channel expression and development of contractility. Cell Physiol Biochem 24:73-86.

Pillekamp F, Halbach M, Reppel M, Pfannkuche K, Nazzal R, Nguemo F, Matzkies M, Rubenchyk O, Hannes T, Khalil M, Bloch W, Sreeram N, Brockmeier K, Hescheler J (2009) Physiological differences between transplanted and host tissue cause functional decoupling after in vitro transplantation of human embryonic stem cell-derived cardiomyocytes. Cell Physiol Biochem 23:65-74.

Protas L, Dun W, Jia Z, Lu J, Bucchi A, Kumari S, Chen M, Cohen IS, Rosen MR, Entcheva E, Robinson RB (2009) Expression of skeletal but not cardiac Na+ channel isoform preserves normal conduction in a depolarized cardiac syncytium. Cardiovasc Res 81:528-535.

Xu XQ, Soo SY, Sun W, Zweigerdt R (2009) Global expression profile of highly enriched cardiomyocytes derived from human embryonic stem cells. Stem Cells 27:2163-2174.

Yeung CK, Sommerhage F, Wrobel G, Law JK, Offenhausser A, Rudd JA, Ingebrandt S, Chan M (2009) To establish a pharmacological experimental platform for the study of cardiac hypoxia using the microelectrode array. J Pharmacol Toxicol Methods 59:146-152.

Caspi O, Itzhaki I, Arbel G, Kehat I, Gepstien A, Huber I, Satin J, Gepstein L (2008) In Vitro Electrophysiological Drug Testing using Human Embryonic Stem Cell Derived Cardiomyocytes. Stem Cells Dev.

Fahrenbach JP, Ai X, Banach K (2008) Decreased intercellular coupling improves the function of cardiac pacemakers derived from mouse embryonic stem cells. J Mol Cell Cardiol.

Habib M, Caspi O, Gepstein L (2008) Human embryonic stem cells for cardiomyogenesis. J Mol Cell Cardiol.

Hannes T, Halbach M, Nazzal R, Frenzel L, Saric T, Khalil M, Hescheler J, Brockmeier K, Pillekamp F (2008) Biological pacemakers: characterization in an in vitro coculture model. J Electrocardiol 41:562-566.

Hofgaard JP, Banach K, Mollerup S, Jorgensen HK, Olesen SP, Holstein-Rathlou NH, Nielsen MS (2008) Phosphatidylinositol-bisphosphate regulates intercellular coupling in cardiac myocytes. Pflugers Arch.

Malan D, Reppel M, Dobrowolski R, Roell W, Smyth N, Hescheler J, Paulsson M, Bloch W, Fleischmann BK (2008) Lack of Laminin {gamma}1 In ES Cell-Derived Cardiomyocytes Causes Inhomogeneous Electrical Spreading Despite Intact Differentiation And Function. Stem Cells.

Mauritz C, Schwanke K, Reppel M, Neef S, Katsirntaki K, Maier LS, Nguemo F, Menke S, Haustein M, Hescheler J, Hasenfuss G, Martin U (2008) Generation of Functional Murine Cardiac Myocytes From Induced Pluripotent Stem Cells. Circulation.

Pijnappels DA, Schalij MJ, Ramkisoensing AA, van Tuyn J, de Vries AA, van der Laarse A, Ypey DL, Atsma DE (2008) Forced Alignment of Mesenchymal Stem Cells Undergoing Cardiomyogenic Differentiation Affects Functional Integration With Cardiomyocyte Cultures. Circ Res.

Reisner Y, Meiry G, Zeevi-Levin N, Barac DY, Reiter I, Abassi Z, Ziv N, Kostin S, Shaper J, Rosen MR, Binah O (2008) Impulse conduction and gap junctional remodeling by endothelin-1 in cultured neonatal rat ventricular myocytes. J Cell Mol Med.

Xu XQ, Zweigerdt R, Soo SY, Ngoh ZX, Tham SC, Wang ST, Graichen R, Davidson B, Colman A, Sun W (2008) Highly enriched cardiomyocytes from human embryonic stem cells. Cytotherapy 10:376-389.

Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM (2008) Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature 453:524-528.

Yankelson L, Feld Y, Bressler-Stramer T, Itzhaki I, Huber I, Gepstein A, Aronson D, Marom S, Gepstein L (2008) Cell therapy for modification of the myocardial electrophysiological substrate. Circulation 117:720-731.

Anderson D, Self T, Mellor IR, Goh G, Hill SJ, Denning C (2007) Transgenic enrichment of cardiomyocytes from human embryonic stem cells. Mol Ther 15:2027-2036.

Barac DY, Reisner Y, Silberman M, Naama ZL, Danon A, Salomon O, Shoham M, Shilkrut M, Kostin S, Schaper J, Binah O (2007) Mechanical load induced by glass microspheres releases angiogenic factors from neonatal rat ventricular myocytes cultures and causes arrhythmias. J Cell Mol Med.

Binah O, Dolnikov K, Sadan O, Shilkrut M, Zeevi-Levin N, Amit M, Danon A, Itskovitz-Eldor J (2007) Functional and developmental properties of human embryonic stem cells-derived cardiomyocytes. J Electrocardiol 40:S192-196.

Grinnemo KH (2007) Cell transplantation with human mesenchymal or embryonic stem cells to the heart.

Harding SE, Ali NN, Brito-Martins M, Gorelik J (2007) The human embryonic stem cell-derived cardiomyocyte as a pharmacological model. Pharmacol Ther 113:341-353.

Hosseinkhani M, Hosseinkhani H, Khademhosseini A, Bolland F, Kobayashi H, Gonzalez SP (2007) Bone morphogenetic protein-4 enhances cardiomyocyte differentiation of cynomolgus monkey ESCs in knockout serum replacement medium. Stem Cells 25:571-580.

Huber I, Itzhaki I, Caspi O, Arbel G, Tzukerman M, Gepstein A, Habib M, Yankelson L, Kehat I, Gepstein L (2007) Identification and selection of cardiomyocytes during human embryonic stem cell differentiation. Faseb J.

Kehat I, Gepstein L (2007) Electrophysiological coupling of transplanted cardiomyocytes. Circ Res 101:433-435.

Pijnappels DA, van Tuyn J, de Vries AA, Grauss RW, van der Laarse A, Ypey DL, Atsma DE, Schalij MJ (2007) Resynchronization of separated rat cardiomyocyte fields with genetically modified human ventricular scar fibroblasts. Circulation 116:2018-2028.

Reppel M, Igelmund P, Egert U, Juchelka F, Hescheler J, Drobinskaya I (2007) Effect of cardioactive drugs on action potential generation and propagation in embryonic stem cell-derived cardiomyocytes. Cell Physiol Biochem 19:213-224.

van Tuyn J, Pijnappels DA, de Vries AA, de Vries I, van der Velde-van Dijke I, Knaan-Shanzer S, van der Laarse A, Schalij MJ, Atsma DE (2007) Fibroblasts from human postmyocardial infarction scars acquire properties of cardiomyocytes after transduction with a recombinant myocardin gene. Faseb J 21:3369-3379.

Jiao Z, De Jesus VR, Iravanian S, Campbell DP, Xu J, Vitali JA, Banach K, Fahrenbach J, Dudley SC, Jr. (2006) A possible mechanism of halocarbon-induced cardiac sensitization arrhythmias. J Mol Cell Cardiol 41:698-705.

Kolossov E, Bostani T, Roell W, Breitbach M, Pillekamp F, Nygren JM, Sasse P, Rubenchik O, Fries JW, Wenzel D, Geisen C, Xia Y, Lu Z, Duan Y, Kettenhofen R, Jovinge S, Bloch W, Bohlen H, Welz A, Hescheler J, Jacobsen SE, Fleischmann BK (2006) Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium. J Exp Med 203:2315-2327.

Natarajan A, Molnar P, Sieverdes K, Jamshidi A, Hickman JJ (2006) Microelectrode array recordings of cardiac action potentials as a high throughput method to evaluate pesticide toxicity. Toxicol In Vitro 20:375-381.

Pijnappels DA, Schalij MJ, van Tuyn J, Ypey DL, de Vries AA, van der Wall EE, van der Laarse A, Atsma DE (2006) Progressive increase in conduction velocity across human mesenchymal stem cells is mediated by enhanced electrical coupling. Cardiovasc Res 72:282-291.

Schwanke K, Wunderlich S, Reppel M, Winkler ME, Matzkies M, Groos S, Itskovitz-Eldor J, Simon AR, Hescheler J, Haverich A, Martin U (2006) Generation and characterization of functional cardiomyocytes from rhesus monkey embryonic stem cells. Stem Cells 24:1423-1432.

Tolmachov O, Ma YL, Themis M, Patel P, Spohr H, Macleod KT, Ullrich ND, Kienast Y, Coutelle C, Peters NS (2006) Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro. BMC Cardiovasc Disord 6:25.

Beeres SL, Atsma DE, van der Laarse A, Pijnappels DA, van Tuyn J, Fibbe WE, de Vries AA, Ypey DL, van der Wall EE, Schalij MJ (2005) Human adult bone marrow mesenchymal stem cells repair experimental conduction block in rat cardiomyocyte cultures. J Am Coll Cardiol 46:1943-1952.

Dolnikov K, Shilkrut M, Zeevi-Levin N, Danon A, Gerecht-Nir S, Itskovitz-Eldor J, Binah O (2005) Functional properties of human embryonic stem cell-derived cardiomyocytes. Ann N Y Acad Sci 1047:66-75.

Kolossov E, Lu Z, Drobinskaya I, Gassanov N, Duan Y, Sauer H, Manzke O, Bloch W, Bohlen H, Hescheler J, Fleischmann BK (2005) Identification and characterization of embryonic stem cell-derived pacemaker and atrial cardiomyocytes. Faseb J 19:577-579.

Liew CG, Moore H, Ruban L, Shah N, Cosgrove K, Dunne M, Andrews P (2005) Human embryonic stem cells: possibilities for human cell transplantation. Ann Med 37:521-532.

Reppel M, Pillekamp F, Brockmeier K, Matzkies M, Bekcioglu A, Lipke T, Nguemo F, Bonnemeier H, Hescheler J (2005) The electrocardiogram of human embryonic stem cell-derived cardiomyocytes. J Electrocardiol 38:166-170.

Rothermel A, Kurz R, Ruffer M, Weigel W, Jahnke HG, Sedello AK, Stepan H, Faber R, Schulze-Forster K, Robitzki AA (2005) Cells on a chip--the use of electric properties for highly sensitive monitoring of blood-derived factors involved in angiotensin II type 1 receptor signalling. Cell Physiol Biochem 16:51-58.

Steiniger J (2005) Signalverarbeitung für zellbasierte Biosensoren. Diplomarbeit FH Aschaffenburg:72.

Xue T, Cho HC, Akar FG, Tsang SY, Jones SP, Marban E, Tomaselli GF, Li RA (2005) Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers. Circulation 111:11-20.

Zeevi-Levin N, Barac YD, Reisner Y, Reiter I, Yaniv G, Meiry G, Abassi Z, Kostin S, Schaper J, Rosen MR, Resnick N, Binah O (2005) Gap junctional remodeling by hypoxia in cultured neonatal rat ventricular myocytes. Cardiovasc Res 66:64-73.

Caspi O, Gepstein L (2004) Potential applications of human embryonic stem cell-derived cardiomyocytes. Ann N Y Acad Sci 1015:285-298.

Egert M (2004) Heart on a Chip - Extracellular Multielectrode Recordings from Cardiac Myocytes in Vitro. Springer:23.

Guenter E (2004) Microelectrode Array - based Biosensors. Screening:2.

Hescheler J, Halbach M, Egert U, Lu ZJ, Bohlen H, Fleischmann BK, Reppel M (2004) Determination of electrical properties of ES cell-derived cardiomyocytes using MEAs. J Electrocardiol 37 Suppl:110-116.

Kehat I, Khimovich L, Caspi O, Gepstein A, Shofti R, Arbel G, Huber I, Satin J, Itskovitz-Eldor J, Gepstein L (2004) Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat Biotechnol 22:1282-1289.

Lee S, Bick-Forrester J, Makkar RR, Forrester JS (2004) Stem-cell repair of infarcted myocardium: ready for clinical application? Am Heart Hosp J 2:100-106.

Meyer T, Boven KH, Gunther E, Fejtl M (2004) Micro-electrode arrays in cardiac safety pharmacology: a novel tool to study QT interval prolongation. Drug Saf 27:763-772.

Meyer T, Leisgen C, Gonser B, Gunther E (2004) QT-screen: high-throughput cardiac safety pharmacology by extracellular electrophysiology on primary cardiac myocytes. Assay Drug Dev Technol 2:507-514.

Reppel M, Boettinger C, Hescheler J (2004) Beta-adrenergic and muscarinic modulation of human embryonic stem cell-derived cardiomyocytes. Cell Physiol Biochem 14:187-196.

Reppel M, Pillekamp F, Lu ZJ, Halbach M, Brockmeier K, Fleischmann BK, Hescheler J (2004) Microelectrode arrays: a new tool to measure embryonic heart activity. J Electrocardiol 37 Suppl:104-109.

Rothermel A, Rüffer M, Urban C, Jahnke HG, Weigel W (2004) A functional cardiomyocyte-based biosensor for Presdiagnostic monitoring: an Angiotensin 2 study. Uni Leipzig:4.

Satin J, Kehat I, Caspi O, Huber I, Arbel G, Itzhaki I, Magyar J, Schroder EA, Perlman I, Gepstein L (2004) Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes. J Physiol 559:479-496.

Banach K, Halbach MD, Hu P, Hescheler J, Egert U (2003) Development of electrical activity in cardiac myocyte aggregates derived from mouse embryonic stem cells. Am J Physiol Heart Circ Physiol 284:H2114-2123.

Halbach M, Egert U, Hescheler J, Banach K (2003) Estimation of action potential changes from field potential recordings in multicellular mouse cardiac myocyte cultures. Cell Physiol Biochem 13:271-284.

Feld Y, Melamed-Frank M, Kehat I, Tal D, Marom S, Gepstein L (2002) Electrophysiological modulation of cardiomyocytic tissue by transfected fibroblasts expressing potassium channels: a novel strategy to manipulate excitability. Circulation 105:522-529.

Hescheler J, Wartenberg M, Fleischmann BK, Banach K, Acker H, Sauer H (2002) Embryonic stem cells as a model for the physiological analysis of the cardiovascular system. Methods Mol Biol 185:169-187.

Kehat I, Gepstein A, Spira A, Itskovitz-Eldor J, Gepstein L (2002) High-resolution electrophysiological assessment of human embryonic stem cell-derived cardiomyocytes: a novel in vitro model for the study of conduction. Circ Res 91:659-661.

Kehat I, Kenyagin-Karsenti D, Snir M, Segev H, Amit M, Gepstein A, Livne E, Binah O, Itskovitz-Eldor J, Gepstein L (2001) Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest 108:407-414.

Meiry G, Reisner Y, Feld Y, Goldberg S, Rosen M, Ziv N, Binah O (2001) Evolution of action potential propagation and repolarization in cultured neonatal rat ventricular myocytes. J Cardiovasc Electrophysiol 12:1269-1277.

Bucher V (2000) Light-adressed sub-um electrodes for extracellular recording and stimulation of excitable cells. Microelectronic Engineering:8.