Wireless-Systems

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Overview

The wireless in vivo systems are the all-in-one solution for amplifying, recording, and analyzing in vivo data from 4, 8, 16 or 32 channels.

The system includes everything you need: Small-sized headstage with integrated A/D converter, digitized transmission, powerful receiver, batteries, as well as a powerful software package.

The most advantageous feature of the Wireless-Systems is the amplification and digitalization of the data on the headstage itself. This way, only digital data is sent to the receiver, which ensures that your data is not diluted or distorted.

With its excellent signal-to-noise ratio, it is the ideal solution for spikes, LFP, EEG, ECG, and ECoG. Additional inputs to the receiver allow the synchronization of the data with external devices.

Synchronized video to data recording is possible with the W2100-Video-System.

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IFB-C

As part of the system, the IFB-C multiboot is a new interface board generation which is able to receive data from a MEA2100(-Mini)-Headstage, a Multiwell-MEA-Headstage, a CMOS-MEA5000-Headstage, a MEA2100-Beta-Screen-Headstage, a ME2100-Headstage, or a W2100-Receiver. This makes cost-effective combinations with only one interface board and multiple recording systems possible. You can establish for example your experiments on 60, 120, or 256 electrodes with the MEA2100-System, then add the Multiwell-MEA-Headstage and start high-throughput screening. It's also possible to use the same interface board for in vitro MEA experiments and tethered / wireless in vivo recordings. This leaves you with even more flexibility in switching between possible configurations for your specific research needs.

Key features:

Real-time signal detection and feedback*
Freely programmable DSP*
Multiple inputs/outputs, including digital, analog, and audio
SuperSpeed USB 3.0 ports

* applicable for MEA2100(-Mini), ME2100, and W2100

Read more technical specifications

Description

Wireless in vivo recording system

The Wireless-System consists of 4 components:

Headstage: Connects to the implanted electrode and digitizes the data. Also available with additional stimulation.
Receiver: Receives the data from the headstage.
Interface board: Provides connection to computer and synchronization with other instruments.
Computer: Included software for data acquisition and analysis (computer itself not included).

Please click on the arrows at the side to learn more about the Wireless-System from Multi Channel Systems.

Video to data synchronization with the W2100-Video-System

As an optional feature to go with the W2100-System, MCS provides high quality USB 3.0 video cameras from IDS to monitor your animals at up to 50 frames/s. A bidirectional communication with TTL signals between W2100-Video-System and the W2100-System allows a precise frame-by-frame synchronization between video and electrophysiological data. One click starts and stops both, camera and data acquisition. Both systems can run on the same PC.

When reviewing the data, it’s possible to jump from one frame in the video to the corresponding time in the W2100 data and vice versa with a single mouse click. Text comments can be added to certain frames of the video off-line. This comment will also show up with an exact timestamp in the data. IR camera options are available on request.

Wireless Probes

Our in vivo recording systems connect to almost all commercially available probes.

Depending on your experiment, you can connect probes for surface recordings or penetrating electrodes with single- or multi-shafts. Our headstages are equipped with single-row or Omnetics connectors, a standard in electrode fabrication.

We recommend the use of probes from NeuroNexus Technologies or ATLAS Neuroengineering. Please see their company websites for probe specifications and order information.

Headstage

The Wireless-Systems can be operated with headstages with 4, 8, 16 or 32 channels. The sockets of the headstage are connected directly to the implanted electrode.

The main advantage of the headstages from Multi Channel Systems is that the data is digitized on the headstage itself and digital data is sent to the receiver. Thereby, noise is minimized and data quality is independent from the distance between headstage and receiver.

Additionally to recording, the headstages also offers options to stimulate. This is made possible by the level-based construction of the headstage. Your headstage can consist of levels for amplification and A/D conversion, electrical or optical stimulation, and motion sensors. Indication for the battery condition as well as an acceleration sensor is always included.

Headstages with recording and stimulation

With the W2100-System, you can use headstages with optical and electrical stimulation.

The biggest advantage of those headstages is that you do not have to give up valuable recording information when stimulating; the headstages can record and stimulate in parallel!

We offer the following headstage types, which are all compatible with all W2100-Systems, so you can easily upgrade your existing system by just adding a new headstage:

Parallel experiments

The Wireless-System offers the possibility to record from four headstages simultaneously with one setup (at a reduced sampling rate).

You can even connect two receivers to one interface board, thereby building a system for up to 8 headstages.

Moreover, you can position four receivers in one room, thereby having a four-fold system with a total of 16 headstages, from which you can record in parallel.

Energy efficiency and flexibility

All devices of the Wireless-System are designed to be energy-efficient. The standard battery of the headstage permits continuous recording of all channels for approx. 2 hours (depends on channel count and sampling rate). Recharging is then realized via a USB charger.
When doing experiments with animals insensitive to weight, we also offer larger batteries, which provide longer recordings. Please contact Multi Channel Systems for more information on battery options.

For power-saving, the headstage switches to stand-by mode when the data acquisition is stopped. When recording continues, the headstage switches on automatically. Another possibility is to switch off the headstage completely via the data acquisition software. When switching on, you can use an infrared flashlight in order to not disturb the animal. Please see the graph below for switching possibilities.

Another possibility for energy-saving is provided by the software. It gives you the opportunity to switch off single channels, simply by deselecting them with one single mouse click. Apart from energy-saving, this feature also offers you the possibility for an even higher sampling rate. For example, a 32-channel headstage can sample all channels at 20 kHz/channel. When reducing the number of recorded channels to 16, the sampling rate is increased to 25kHz/channel. This way, you can always decide to look at some channels in even more detail.

Flexible battery placement

For maximum flexibility, we offer headstages with connections to all probes. Just let us know which probe you want to use and we will provide the corresponding connector.

Moreover, depending on your experiment, you can also decide where to position the battery of the headstage. Either fix it on the headstage itself or use a special backpack for the cable-connected battery. Independent of your decision, be sure that the battery is small and lightweight in order to not influence your experiment.

Computer and software

The last component of the system is the computer with the software package Multi Channel Suite. The computer is not included in the scope of delivery; however, you can use any computer with a USB connector. What is included, is the Multi Channel Suite software.

It consists of three programs and updates are available for free here.

Multi Channel Experimenter is the data acquisition and online analysis tool. With an easy-to-use drag’n’drop interface, you simply create your virtual experiment with e.g. data source, filters, spike detection, and recorder. The software indicates the battery level and signal quality and displays the data in real-time.
Multi Channel Analyzer is the offline analysis tool. You just import the data recorded with the Multi Channel Experimenter and then define your in-depth analysis with more instruments. The Multi Channel Analyzer also supports synchronized video input. This is an advantageous feature when doing behavioral research with freely moving animals. The video data and electrophysiological recordings are displayed in parallel and you can easily skip through the data from one event to the next.
Multi Channel DataManager facilitates the data export for analysis with third-party programs. It supports all files generated with the Multi Channel Experimenter and then exports the data into HDF5 (e.g. Matlab, Python), .nex (Neuroexplorer) or .ced (Spike 2). Independent of the file format, the export is done quickly and a data compresssion is included.

Interface board

The interface board receives data from the headstage via a iX industrial type B cable. In the interface board, you find a freely programmable digital signal processor, which can be used for real-time signal detection and feedback. Moreover, you find various analog and digital in- and outputs for synchronization with other instruments. The interface board connects to the computer via USB 3.0 SuperSpeed. The IFB-C is a new interface board generation which is able to receive data from MEA2100-Headstages, Multiwell-MEA-Headstage, CMOS-MEA5000-Headstage, ME2100-Systems or W2100-Systems. This makes cost-effective combinations with only one interface board and multiple recording systems possible.

IFB-C

Support and Sales team: Always there for you

Multi Channel Systems has a team of highly-qualified scientists, whose only task is to help you with any issue you might have. No matter whether you want to know whether your biological sample is suitable for MEA recordings or if you have a specific software question: Our support team is here to help you.

We have scientists who earned their PhDs in the fields of biology, biophysics, and biochemistry and specialized in:

Neuronal electrophysiology
Cardiac electrophysiology
Xenopus oocyte research
Patch Clamp

Our sales team has years of experience in electrophysiology, too. They can help you in choosing the right system for your specific application, give you advice on the general set-up and useful accessories. They are happy to visit you in your lab anytime to:

Make a demonstration of our systems
Help you with the installation of a new system
Give you training on hard- and software
Discuss any issues you might have with your application

Worldwide, we are supported by our distribution partners. We have long-lasting cooperations with all of our partners and they are regularly trained on our equipment. Be sure that they have the expertise to advise you on all MCS-Systems.

Please do not hesitate to contact us. Normally, we reply to you within 24 hours. You can contact us via:

Phone +49 7121 90925 25
Email support [at] multichannelsystems.com (Support Team); sales [at] multichannelsystems.com (Sales Team)
Contact form

Benefits

The Wireless Systems from Multi Channel Systems offer the following benefits:

Excellent signal-to-noise ratio due to digitization on headstage
16-bit resolution
Lightweight headstage
Wide effective range (5 m)
Flexible battery options
Options for electrical and optical stimulation (advanced system)
Synchronized video to data recording with the W2100-Video-System

Products

Documents

Manual:

MCS_W2100-System_Manual.pdf

Multi Channel VideoControl_Manual.pdf

Data sheet:

W2100-System HS Overview.pdf

Brochure:

W2100-System_Brochure.pdf

Accessories

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Products

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Documents

Data sheet:

W2100-System HS Overview.pdf

Publications

Please note: Currently, our publications library includes articles up to 2021 only. Contact us for publications from 2022 – present.Contact Us

Borda E, Ferlauto L, Schleuniger J, Mustaccio A, Lütolf F, Lücke A, Fricke S, Marjanović N, Ghezzi D (2020) All-Printed Electrocorticography Array for In Vivo Neural Recordings. Advanced Engineering Materials n/a:1901403.

Deffains M, Haï Nguyen T, Orignac H, Biendon N, Dovero S, Bezard E, Boraud T (2020) In vivo electrophysiological validation of DREADD-based inhibition of pallidal neurons in the non-human primate. bioRxiv:2020.2001.2003.893610.

Hasbi A, Nguyen T, Rahal H, Manduca JD, Miksys S, Tyndale RF, Madras BK, Perreault ML, George SR (2020) Sex difference in dopamine D1-D2 receptor complex expression and signaling affects depression- and anxiety-like behaviors. Biol Sex Differ 11:8.

Reasmussen D (2020) Effect of Ketamine Treatment on Neuronal Oscillatory Activity in the Nucleus Accumbens and Hippocampus in an Animal Model of Treatment-Resistant Depression.

Cosset E, Locatelli M, Marteyn A, Lescuyer P, Dall Antonia F, Mor FM, Preynat-Seauve O, Stoppini L, Tieng V (2019) Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases. J Vis Exp.

Foute Nelong MT, Manduca JD, Zonneveld PM, Perreault ML (2019) Asenapine Maleate normalizes low frequency oscillatory deficits in a neurodevelopmental model of schizophrenia. Neurosci Lett:134404.

Iturra-Mena AM, Aguilar-Rivera M, Arriagada-Solimano M, Pérez-Valenzuela C, Fuentealba P, Dagnino-Subiabre A (2019) Impact of Stress on Gamma Oscillations in the Rat Nucleus Accumbens During Spontaneous Social Interaction. Frontiers in Behavioral Neuroscience 13.

Jacob S, Davies G, De Bock M, Hermans B, Wintmolders C, Bottelbergs A, Borgers M, Theunis C, Van Broeck B, Manyakov NV, Balschun D, Drinkenburg W (2019) Neural oscillations during cognitive processes in an App knock-in mouse model of Alzheimer's disease pathology. Sci Rep 9:16363.

Karamihalev S, Flachskamm C, Kimura M, Chen A (2019) Social context and dominance status contribute to sleep patterns and quality in groups of freely-moving mice. bioRxiv:529669.

Loonen ICM, Jansen NA, Cain SM, Schenke M, Voskuyl RA, Yung AC, Bohnet B, Kozlowski P, Thijs RD, Ferrari MD, Snutch TP, van den Maagdenberg A, Tolner EA (2019) Brainstem spreading depolarization and cortical dynamics during fatal seizures in Cacna1a S218L mice. Brain 142:412-425.

Shimell JJ, Shah BS, Cain SM, Thouta S, Kuhlmann N, Tatarnikov I, Jovellar DB, Brigidi GS, Kass J, Milnerwood AJ, Snutch TP, Bamji SX (2019) The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation. Cell Rep 29:2422-2437 e2428.

Thériault R-K, Manduca JD, Perreault ML (2019) Sex differences in innate and adaptive neural oscillatory patterns predict resilience and susceptibility to chronic stress in rats. bioRxiv:720011.

Albrecht MA, Vaughn CN, Erickson MA, Clark SM, Tonelli LH (2018) Time and frequency dependent changes in resting state EEG functional connectivity following lipopolysaccharide challenge in rats. PLoS ONE 13:e0206985.

Ferlauto L, D'Angelo AN, Vagni P, Airaghi Leccardi MJI, Mor FM, Cuttaz EA, Heuschkel MO, Stoppini L, Ghezzi D (2018) Development and Characterization of PEDOT:PSS/Alginate Soft Microelectrodes for Application in Neuroprosthetics. Front Neurosci 12:648.

Georgescu EL, Georgescu IA, Zahiu CDM, Steopoaie AR, Morozan VP, Pana AS, Zagrean AM, Popa D (2018) Oscillatory Cortical Activity in an Animal Model of Dystonia Caused by Cerebellar Dysfunction. Front Cell Neurosci 12:390.

Lensu S, Waselius T, Penttonen M, Nokia MS (2018) Dentate spikes and learning: Disrupting hippocampal function during memory consolidation can improve pattern separation. J Neurophysiol.

Waselius T, Wikgren J, Halkola H, Penttonen M, Nokia MS (2018) Learning by heart: Cardiac cycle reveals an effective time window for learning. J Neurophysiol.

Jiang Z, Huxter JR, Bowyer SA, Blockeel AJ, Butler J, Imtiaz SA, Wafford KA, Phillips KG, Tricklebank MD, Marston HM, Rodriguez-Villegas E (2017) TaiNi: Maximizing research output whilst improving animals' welfare in neurophysiology experiments. Sci Rep 7:8086.

Lecomte A, Degache A, Descamps E, Dahan L, Bergaud C (2017) In vitro and in vivo biostability assessment of chronically-implanted Parylene C neural sensors. Sensors and Actuators B: Chemical.

Cain SM, Ahn S, Garcia E, Zhang Y, Waheed Z, Tyson JR, Yang Y, Van Sung T, Phillips AG, Snutch TP (2016) Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing. Mol Brain 9:94.

Marks WN, Cain SM, Snutch TP, Howland JG (2016) The T-type calcium channel antagonist Z944 rescues impairments in crossmodal and visual recognition memory in Genetic Absence Epilepsy Rats from Strasbourg. Neurobiol Dis 94:106-115.

Marks WN, Cavanagh ME, Greba Q, Cain SM, Snutch TP, Howland JG (2016) The Genetic Absence Epilepsy Rats from Strasbourg model of absence epilepsy exhibits alterations in fear conditioning and latent inhibition consistent with psychiatric comorbidities in humans. Eur J Neurosci 43:25-40.

Zhou ZC, Yu C, Sellers KK, Frohlich F (2016) Dorso-Lateral Frontal Cortex of the Ferret Encodes Perceptual Difficulty during Visual Discrimination. Sci Rep 6:23568.

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Innovations in Electrophysiology

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IFB-C

Key features:

W2100-System-AO

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IFB-C

W2100-Video-System

W2100-Video-System-NIR

W2100-HS4

W2100-HS4-opto

W2100-HS8

W2100-HS8-SR

W2100-HS8-opto

W2100-HS8-SR-opto

W2100-HS8-ES2-0.5mA

W2100-HS8-ES2-2.0mA

W2100-HS8-ES2-EXT-0.5mA

W2100-HS8-ES2-EXT-2.0mA

W2100-HS8-SR-ES2-EXT-0.5mA

W2100-HS8-SR-ES2-EXT-2.0mA

W2100-HS14-ES2-0.5mA

W2100-HS14-ES2-2.0mA

W2100-HS16

W2100-HS16-opto

W2100-HS16-ES2-EXT-0.5mA

W2100-HS16-ES2-EXT-2.0mA

W2100-HS32

W2100-HS32-opto

W2100-HS32-ES2-EXT-0.5mA

W2100-HS32-ES2-EXT-2.0mA

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Wireless-Systems

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IFB-C

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