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Innovations in Electrophysiology

Ion Channel Electrophysiology

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Xenopus laevis Electrophysiology

JoVE Video

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Cardiac Na+ Channels

Cardiac Na+ Channels
Category: 
Applications
Ion Channel Electrophysiology

These voltage-gated channels initiate action potentials in excitable cells. Local anesthetics such as lidocaine block Na+ channels and have been used to manage cardiac arrhythmias, and non-specific drug binding to the SCN5A channel can alter normal cardiac rhythm.

GABAA Receptors

GABAA Receptors
Category: 
Applications
Ion Channel Electrophysiology

GABAA receptors are targets for many clinically important drugs like anxiolytics, anticonvulsants, anesthetics, sedatives, muscle relaxants, barbiturates, and benzodiazepines.

hERG Channels

Category: 
Applications
Ion Channel Electrophysiology

hERG channels critically contribute to cardiac repolarization. Drugs blocking these channels can lead to a prolongation of the action potential. Also, inhibition of hERG due to unwanted drug side effects means a significant risk factor for cardiac safety.

IKs Currents (KCNE1)

IKs Currents (KCNE1)
Category: 
Applications
Ion Channel Electrophysiology

Mutations in these ion channels lead to disorders that may increase the risk of death from cardiac arrhythmia (long QT syndrome or LQTS) and Jervell and Lange-Nielsen syndrome, associated with congenital deafness.

Kv4.3 K+ Channels

Kv4.3 K+ Channels
Category: 
Applications
Ion Channel Electrophysiology

Kv4.3 channels display rapidly inactivating K+ currents in brain and heart, which regulate neuronal firing and heart pacing. Altered Kv4.3 expression occurs under pathological conditions like heart failure.

nACh Receptors

nACh Receptors
Category: 
Applications
Ion Channel Electrophysiology

nAChRs play a key role in the signal transmission between cells at the nerve/muscle synapses. Various studies demonstrated their involvement in high brain functions and in important neurodegenerative pathologies.

P2X Receptors

P2X Receptors
Category: 
Applications
Ion Channel Electrophysiology

P2X receptors are nucleotide-gated cation channels playing important physiological and pathophysiological roles and are therefore promising targets for drug development.

Sodium Pump

Sodium Pump
Category: 
Applications
Ion Channel Electrophysiology

The Na/K-ATPase or Na-pump is the pharmacological receptor for cardiac glycosides, which are widely used in the treatment of heart failure. Furthermore, it is possibly also the physiological receptor for endogenous ouabain compounds.